GATA4, an essential cardiogenic transcription factor, provides a model for dominant transcription
factor mutations in human disease. Dominant GATA4 mutations cause congenital heart …

Congenital Heart Disease (CHD), malformations of the heart present at birth, is the most
common class of life-threatening birth defect (Hoffman (1995) [1], Gelb (2004) [2], Gelb (2014) [3]…

The mechanisms used by embryos to pattern tissues across their axes has fascinated
developmental biologists since the founding of embryology. Here, using single-cell technology, we …

Many developmental signaling pathways have been implicated in lineage-specific differentiation;
however, mechanisms that explicitly control differentiation timing remain poorly defined …

New genes (or young genes) are structural novelties pivotal in mammalian evolution. Their
phenotypic impacts on humans, however, remain elusive due to the technical and ethical …

Hedgehog (Hh) signaling acts as a developmental morphogen that contributes to the
diversification of cell fates and tissue patterning in multiple embryonic contexts, as well as …

The anterior-posterior (AP) axis of the vertebrate body plan is established during gastrulation,
as mesoderm is progressively generated and patterned by signaling from the posterior …

The first heart field (FHF) and the second heart field (SHF) comprise the major progenitor
pools for the developing vertebrate heart. We investigated the delayed differentiation of the …

Neonates possess a molecular variant of fibrinogen, known as fetal fibrinogen, characterized
by increased sialic acid, a greater negative charge, and decreased activity compared with …

Gene regulation is a tightly controlled process that when disrupted can cause a multitude of
cellular defects, increased disease risk, and in some cases disease itself. In order to …