Substance use disorders commonly co-occur with one another and with other psychiatric
disorders. They share common features including high impulsivity, negative affect, and lower …

Magnetic resonance imaging (MRI) has transformed our understanding of the human brain
through well-replicated mapping of abilities to specific structures (for example, lesion studies) …

Background Variation in liability to cannabis use disorder has a strong genetic component (estimated
twin and family heritability about 50–70%) and is associated with negative …

Laboratory executive function (EF) constructs, such as response inhibition, are often conceptually
linked with self-report measures of impulsivity, yet their empirical correlations are low. …

Importance In light of increasing cannabis use among pregnant women, the US Surgeon
General recently issued an advisory against the use of marijuana during pregnancy. Objective …

Magnetic resonance imaging (MRI) continues to drive many important neuroscientific
advances. However, progress in uncovering reproducible associations between individual …

Genetic liability to substance use disorders can be parsed into loci that confer general or
substance-specific addiction risk. We report a multivariate genome-wide association meta-…

Despite the large toll of opioid use disorder (OUD), genome-wide association studies (GWAS)
of OUD to date have yielded few susceptibility loci. We performed a large-scale GWAS of …

Problematic alcohol use (PAU), a trait that combines alcohol use disorder and alcohol-related
problems assessed with a questionnaire, is a leading cause of death and morbidity …

The growing prevalence of opioid use disorder (OUD) constitutes an urgent health crisis.
Ample evidence indicates that risk for OUD is heritable. As a surrogate (or proxy) for OUD, we …