Under the right conditions, some biological systems can maintain high viability after being
frozen and thawed, but many others (eg, organs and many mammalian cells) cannot. To …

Cardiac fibrosis is a pathological process characterized by excessive tissue deposition,
matrix remodeling, and tissue stiffening, which eventually leads to organ failure. On a cellular …

Controlling and predicting unwanted degradation, such as non-native aggregation, is a long-standing
challenge for mAbs and other protein-based products. mAb aggregation rates are …

Myofibroblasts are a highly secretory and contractile cell phenotype that are predominant in
wound healing and fibrotic disease. Traditionally, myofibroblasts are identified by the de …

The native extracellular matrix (ECM) is composed of hierarchically structured biopolymers
containing precise monomer sequences and chain shapes to yield bioactivity. Recapitulating …

Human mesenchymal stromal cells (hMSCs) are multipotent cells that have been proposed
for cell therapies due to their immunosuppressive capacity that can be enhanced in the …

Enhancing materials with the qualities of living systems, including sensing, computation,
and adaptation, is an important challenge in designing next-generation technologies. Living …

Vascularization of engineered scaffolds remains a critical obstacle hindering the translation
of tissue engineering from the bench to the clinic. We previously demonstrated the robust …

Through the postpolymerization modification of poly(allyl glycidyl ether) (PAGE), a functionalizable
polyether with a poly(ethylene oxide) backbone, we engineered a new class of highly …

Optimizing the performance of asymmetric membranes prepared via nonsolvent-induced
phase separation (NIPS) requires a quantitative understanding of how processing variables …