Nuclear localization of the transcriptional activator NF-κB (nuclear factor κB) is controlled in
mammalian cells by three isoforms of NF-κB inhibitor protein: IκBα, -β, and -ɛ. Based on …

The nuclear factor kappa B ( NFκB ) family of transcription factors is a key regulator of immune
development, immune responses, inflammation, and cancer. The NFκB signaling system (…

Nuclear receptors (NRs) repress transcriptional responses to diverse signaling pathways as
an essential aspect of their biological activities, but mechanisms determining the specificity …

Over the past few years, the transcription factor nuclear factor (NF)‐κB and the proteins that
regulate it have emerged as a signaling system of pre‐eminent importance in human …

Hypoxic response and inflammation both involve the action of the hypoxia-inducible transcription
factors HIF-1α and HIF-2α. Previous studies have revealed that both HIF-α proteins are …

We describe a broad mechanistic framework for the transcriptional induction of mammalian
primary response genes by Toll-like receptors and other stimuli. One major class of primary …

A small number of mammalian signaling pathways mediate a myriad of distinct physiological
responses to diverse cellular stimuli. Temporal control of the signaling module that contains …

Tay–Sachs and Sandhoff diseases are clinically similar neurodegenerative disorders. These
two sphingolipidoses are characterized by a heritable absence of β–hexosaminidase A …

Two distinct nuclear factor κB (NFκB) signaling pathways have been described; the canonical
pathway that mediates inflammatory responses, and the non-canonical pathway that is …

Inflammatory NF-κB/RelA activation is mediated by the three canonical inhibitors, IκBα, -β,
and -ɛ. We report here the characterization of a fourth inhibitor, nfκb2/p100, that forms two …