Objective— Inflammation and dysregulated angiogenesis are features of endothelial dysfunction
in pulmonary hypertension. Neutrophil extracellular traps (NETs), produced by dying …

Much of the functionality of multicellular systems arises from the spatial organization and
dynamic behaviours within and between cells. Current single-cell genomic methods only …

Organs-on-a-Chip (OOAC) is a disruptive technology with widely recognized potential to
change the efficiency, effectiveness, and costs of the drug discovery process; to advance …

Pulmonary arterial hypertension (PAH) is a severe disorder of lung vasculature that causes
right heart failure. Homoeostatic effects of flow-activated transcription factor Krüppel-like …

Pulmonary arterial hypertension (PAH) is an unmet clinical need. The lack of models of
human disease is a key obstacle to drug development. We present a biomimetic model of …

Rete ridges consist of undulations between the epidermis and dermis that enhance the
mechanical properties and biological function of human skin. However, most human skin models …

Printing human tissue constructs replete with biomimetic vascular networks is of growing
interest for tissue and organ engineering. While it is now possible to embed perfusable …

The mechanisms by which physical forces regulate endothelial cells to determine the
complexities of vascular structure and function are enigmatic 1 , 2 , 3 , 4 , 5 . Studies of sensory …

Flow-activated transcription factor Krüppel-like factor 2 (KLF2) signaling is compromised in
pulmonary arterial hypertension (PAH). We aimed to identify KLF2-induced endothelium-…

The environmental impact of shale oil and gas production by hydraulic fracturing (fracking)
is of increasing concern. The biggest potential source of environmental contamination is …