Parkinson's disease (PD) is a common neurodegenerative disorder characterized by loss of
dopaminergic neurons in the substantia nigra. Several lines of evidence strongly implicate …

Loss-of-function mutations in the PTEN-induced kinase 1 (PINK1) or parkin genes, which
encode a mitochondrially localized serine/threonine kinase and a ubiquitin-protein ligase, …

Loss of the E3 ubiquitin ligase Parkin causes early onset Parkinson's disease, a neurodegenerative
disorder of unknown etiology. Parkin has been linked to multiple cellular processes …

Mutations in PTEN-induced kinase 1 (PINK1) cause early onset autosomal recessive
Parkinson's disease (PD). PINK1 is a 63 kDa protein kinase, which exerts a neuroprotective …

Loss-of-function mutations of the parkin gene are a major cause of early-onset parkinsonism.
To explore the mechanism by which loss of parkin function results in neurodegeneration, …

A GGGGCC hexanucleotide repeat expansion in the C9orf72 gene is the most common
genetic cause of amyotrophic lateral sclerosis and frontotemporal dementia (C9 ALS / FTD ). …

Parkinson's disease (PD) is a common neurodegenerative disorder that displays both sporadic
and inherited forms [1]. Exposure to several common environmental toxins acting through …

Compelling evidence indicates that two autosomal recessive Parkinson's disease genes,
PINK1 (PARK6) and Parkin (PARK2), cooperate to mediate the autophagic clearance of …

Mutations in PINK1 and PARK2 cause autosomal recessive parkinsonism, a neurodegenerative
disorder that is characterized by the loss of dopaminergic neurons. To discover potential …

While mitochondrial dysfunction is emerging as key in Parkinson's disease (PD), a central
question remains whether mitochondria are actual disease drivers and whether boosting …