Recent advances in synthetic biology and biological system engineering have allowed the
design and construction of engineered live biotherapeutics targeting a range of human …

A distributed biological system can be defined as a system whose components are located
in different subpopulations, which communicate and coordinate their actions through …

Multi-species microbial communities are widespread in natural ecosystems. When
employed for biomanufacturing, engineered synthetic communities have shown increased …

Microbial species rarely exist in isolation. In naturally occurring microbial systems there is
strong evidence for a positive relationship between species diversity and productivity of …

Plasmids are the workhorse of both industrial biotechnology and synthetic biology, but
ensuring they remain in bacterial cells is a challenge. Antibiotic selection cannot be used to …

Many complex behaviors in biological systems emerge from large populations of interacting
molecules or cells, generating functions that go beyond the capabilities of the individual …

The scope of bioengineering is expanding from the creation of single strains to the design of
microbial communities, allowing for division-of-labour, specialised sub-populations and …

Predictability is a fundamental requirement in biological engineering. As we move to
building coordinated multicellular systems, the potential for such systems to display chaotic …

Background Genetic switches exhibit multistability, form the basis of epigenetic memory,
and are found in natural decision making systems, such as cell fate determination in …

The measurement of gene expression using fluorescence markers has been a cornerstone
of synthetic biology for the past two decades. However, the use of arbitrary units has limited …