Amino acids (aa) are not only building blocks for proteins, but also signalling molecules,
with the mammalian target of rapamycin complex 1 (mTORC1) acting as a key mediator. …

Ras GTPase-activating protein-binding proteins 1 and 2 (G3BP1 and G3BP2, respectively)
are widely recognized as core components of stress granules (SGs). We report that G3BPs …

Phosphorylation-dependent signal transduction plays an important role in regulating the
functions and fate of skeletal muscle cells. Central players in the phospho-signaling network are …

Seizure threshold 2 (SZT2) is a component of the KICSTOR complex which, under catabolic
conditions, functions as a negative regulator in the amino acid-sensing branch of mTORC1. …

With increasing sensitivity and accuracy in mass spectrometry, the tumor phosphoproteome
is getting into reach. However, the selection of quantitation techniques best-suited to the …

Limited supply and catabolism restrict the essential amino acid tryptophan (Trp) in tumors.
How tumors sustain translation under Trp stress remains unclear. Unlike other amino acids, …

G3BP1 (Ras GTPase-activating protein-binding protein 1) is widely recognized as a core
component of stress granules (SG), non-membranous RNA-protein-assemblies required for …

Tumors are prime examples of cell growth in unfavorable environments that elicit cellular
stress. The high metabolic demand and insufficient vascularization of tumors cause a …

All cells and organisms exhibit stress-coping mechanisms to ensure survival. Cytoplasmic
protein-RNA assemblies termed stress granules are increasingly recognized to promote …

Mechanistic target of rapamycin complex 1 (MTORC1) and polo like kinase 1 (PLK1) are
major drivers of cancer cell growth and proliferation, and inhibitors of both protein kinases are …