The dendritic actin network generated by the Arp2/3 complex in lamellipodia underlies
formation of protrusions, directional sensing, and migration. While the generation of this network …

The ATR protein is a member of the phosphoinositide 3-kinase-related kinase family and
plays an important role in UV-induced DNA damage checkpoint response. Its role as a signal …

Gel-forming mucins are the largest complex glycoprotein macromolecules in the body. They
form the matrix of gels protecting all the surface epithelia and are secreted as disulfide-…

Since its discovery in 1969, enterovirus 71 (EV71) has emerged as a serious worldwide
health threat. This human pathogen of the picornavirus family causes hand, foot, and mouth …

Inosine monophosphate dehydrogenase (IMPDH), a rate-limiting enzyme in the de novo
synthesis of guanine nucleotides, is a major therapeutic target. A prototypic uncompetitive …

Coronins are conserved F-actin binding proteins that have been implicated in a variety of
processes including fibroblast migration, phagocytosis, and chemotaxis. Recent data from our …

Human papillomavirus replication initiator, the E1 helicase, binds weakly to the origin of
DNA replication. Purified human chaperone proteins Hsp70 and Hsp40 (HDJ-1 and HDJ-2) …

Three mitochondrial metabolic pathways are required for efficient energy production in
eukaryotic cells: the electron transfer chain (ETC), fatty acid β-oxidation (FAO), and the …

Human papillomavirus (HPV) is a significant health burden and leading cause of virus-induced
cancers. The current commercial vaccines are genotype specific and provide little …

The herpesvirus capsid is a complex protein assembly that includes hundreds of copies of
four major subunits and lesser numbers of several minor proteins, all of which are essential …