User profiles for Alexander Mietke

Alexander Mietke

University of Oxford
Verified email at physics.ox.ac.uk
Cited by 1906

Odd dynamics of living chiral crystals

TH Tan, A Mietke, J Li, Y Chen, H Higinbotham… - Nature, 2022 - nature.com
Active crystals are highly ordered structures that emerge from the self-organization of motile
objects, and have been widely studied in synthetic 1 , 2 and bacterial 3 , 4 active matter. …

Real-time deformability cytometry: on-the-fly cell mechanical phenotyping

O Otto, P Rosendahl, A Mietke, S Golfier, C Herold… - Nature …, 2015 - nature.com
We introduce real-time deformability cytometry (RT-DC) for continuous cell mechanical
characterization of large populations (>100,000 cells) with analysis rates greater than 100 cells/s. …

[PDF][PDF] Extracting cell stiffness from real-time deformability cytometry: theory and experiment

A Mietke, O Otto, S Girardo, P Rosendahl… - Biophysical journal, 2015 - cell.com
Cell stiffness is a sensitive indicator of physiological and pathological changes in cells, with
many potential applications in biology and medicine. A new method, real-time deformability …

Numerical simulation of real-time deformability cytometry to extract cell mechanical properties

M Mokbel, D Mokbel, A Mietke, N Traber… - ACS Biomaterials …, 2017 - ACS Publications
The measurement of cell stiffness is an important part of biological research with diverse
applications in biology, biotechnology and medicine. Real-time deformability cytometry (RT-DC) …

Self-organized shape dynamics of active surfaces

A Mietke, F Jülicher… - Proceedings of the …, 2019 - National Acad Sciences
Mechanochemical processes in thin biological structures, such as the cellular cortex or epithelial
sheets, play a key role during the morphogenesis of cells and tissues. In particular, they …

Direct visualization of the subthalamic nucleus and its iron distribution using high‐resolution susceptibility mapping

…, J Neumann, S Wharton, A Mietke… - Human brain …, 2012 - Wiley Online Library
Histological studies have shown a relatively high iron concentration in the subthalamic
nucleus (STN). T2‐ and T2*‐weighted sequences have previously been used to visualize the …

Attachment of the blastoderm to the vitelline envelope affects gastrulation of insects

S Münster, A Jain, A Mietke, A Pavlopoulos, SW Grill… - Nature, 2019 - nature.com
During gastrulation, physical forces reshape the simple embryonic tissue to form the complex
body plans of multicellular organisms 1 . These forces often cause large-scale asymmetric …

Learning hydrodynamic equations for active matter from particle simulations and experiments

…, A Hastewell, GPT Choi, A Mietke… - Proceedings of the …, 2023 - National Acad Sciences
Recent advances in high-resolution imaging techniques and particle-based simulation methods
have enabled the precise microscopic characterization of collective dynamics in various …

High‐throughput cell mechanical phenotyping for label‐free titration assays of cytoskeletal modifications

S Golfier, P Rosendahl, A Mietke, M Herbig… - …, 2017 - Wiley Online Library
The mechanical fingerprint of cells is inherently linked to the structure of the cytoskeleton
and can serve as a label‐free marker for cell homeostasis or pathologic states. How …

Minimal model of cellular symmetry breaking

A Mietke, V Jemseena, KV Kumar, IF Sbalzarini… - Physical review …, 2019 - APS
The cell cortex, a thin film of active material assembled below the cell membrane, plays a
key role in cellular symmetry-breaking processes such as cell polarity establishment and cell …