Background The management of warfarin therapy is complicated by a wide variation among
patients in drug response. Variants in the gene encoding vitamin K epoxide reductase …

Tobacco and alcohol use are leading causes of mortality that influence risk for many complex
diseases and disorders 1 . They are heritable 2 , 3 and etiologically related 4 , 5 behaviors …

The Trans-Omics for Precision Medicine (TOPMed) programme seeks to elucidate the genetic
architecture and biology of heart, lung, blood and sleep disorders, with the ultimate goal of …

Stroke has multiple etiologies, but the underlying genes and pathways are largely unknown.
We conducted a multiancestry genome-wide-association meta-analysis in 521,612 …

Age is the dominant risk factor for most chronic human diseases, but the mechanisms
through which ageing confers this risk are largely unknown 1 . The age-related acquisition of …

Estimates of biological age based on DNA methylation patterns, often referred to as “epigenetic
age”,“DNAm age”, have been shown to be robust biomarkers of age in humans. We …

Myocardial infarction (MI), a leading cause of death around the world, displays a complex
pattern of inheritance 1 , 2 . When MI occurs early in life, genetic inheritance is a major …

Genome-wide association studies (GWAS) have laid the foundation for investigations into the
biology of complex traits, drug development and clinical guidelines. However, the majority …

Background Various genome-wide association studies (GWAS) have been done in ischaemic
stroke, identifying a few loci associated with the disease, but sample sizes have been …

Background Epigenetic biomarkers of aging (the “epigenetic clock”) have the potential to
address puzzling findings surrounding mortality rates and incidence of cardio-metabolic …