Noncanonical hedgehog pathway activation through SRF–MKL1 promotes drug resistance in basal cell carcinomas

…, A Lee, NM Urman, A Mirza, CY Yao, AS Brown… - Nature medicine, 2018 - nature.com
Hedgehog pathway–dependent cancers can escape Smoothened (SMO) inhibition through
mutations in genes encoding canonical hedgehog pathway components; however, around …

[HTML][HTML] A large-scale genome-wide association study meta-analysis of cannabis use disorder

…, R Wedow, DE Adkins, AE Adkins, J Alexander… - The Lancet …, 2020 - thelancet.com
Background Variation in liability to cannabis use disorder has a strong genetic component (estimated
twin and family heritability about 50–70%) and is associated with negative …

Genome Sequence of Aedes aegypti, a Major Arbovirus Vector

…, EM Zdobnov, NF Lobo, KS Campbell, SE Brown… - Science, 2007 - science.org
We present a draft sequence of the genome of Aedes aegypti, the primary vector for yellow
fever and dengue fever, which at ∼1376 million base pairs is about 5 times the size of the …

Career choice barriers, supports, and coping strategies: College students' experiences

…, T Davis, SB Chopra, MS Alexander… - Journal of Vocational …, 2002 - Elsevier
This study used qualitative methods to examine the perceived influences on college students'
selection and implementation of career choices. Students at two universities participated in …

Subretinal hyperreflective material in the comparison of age-related macular degeneration treatments trials

…, S Brown, BJ Ciscato, JM Civantos, C Figliulo, S Hasan… - Ophthalmology, 2015 - Elsevier
Purpose To evaluate the association of subretinal hyperreflective material (SHRM) with visual
acuity (VA), geographic atrophy (GA), and scar in the Comparison of Age-Related Macular …

Fistula first is not always the best strategy for the elderly

…, Y Vin, A Narra, V Chawla, RS Brown… - Journal of the …, 2013 - journals.lww.com
Whether placing a fistula first is the superior predialysis approach among octogenarians is
unknown. We analyzed data from a cohort of 115,425 incident hemodialysis patients≥ 67 …

The survival benefit of “fistula first, catheter last” in hemodialysis is primarily due to patient factors

RS Brown, BK Patibandla… - Journal of the …, 2017 - journals.lww.com
Patients needing hemodialysis are advised to have arteriovenous fistulas rather than catheters
because of significantly lower mortality rates. However, disparities in fistula placement …

Assessment of a renal angina index for prediction of severe acute kidney injury in critically ill children: a multicentre, multinational, prospective observational study

…, S Alexander, M Festa, D Hahn, L Brown… - The Lancet Child & …, 2018 - thelancet.com
Background Acute kidney injury occurs in one in four children admitted to an intensive care
unit (ICU) and its severity is independently associated with increased patient morbidity and …

Mushrooms, trees, and money: value estimates of commercial mushrooms and timber in the Pacific Northwest

SJ Alexander, D Pilz, NS Weber, E Brown… - Environmental …, 2002 - Springer
Wild edible mushrooms are harvested in the forests of the Pacific Northwest, where both trees
and mushrooms grow in the same landscape. Although there has been some discussion …

Preoperative gabapentin for acute post‐thoracotomy analgesia: a randomized, double‐blinded, active placebo‐controlled study

…, DA Wigle, SL Hoehn, SL Alexander… - Pain …, 2012 - Wiley Online Library
Background: The role of preoperative gabapentin in postoperative pain management is not
clear, particularly in patients receiving regional blockade. Patients undergoing thoracotomy …