The distribution of 20 variable regions resulting from insertion-deletion events in the
genomes of the tubercle bacilli has been evaluated in a total of 100 strains of Mycobacterium …

Although large human populations have been safely immunized against tuberculosis with
two live vaccines, Mycobacterium bovis BCG or Mycobacterium microti, the vole bacillus, the …

The live tuberculosis vaccines Mycobacterium bovis BCG (bacille Calmette-Guérin) and
Mycobacterium microti both lack the potent, secreted T-cell antigens ESAT-6 (6-kDa early …

Bedaquiline, a diarylquinoline, improved cure rates when added to a multidrug-resistant
tuberculosis (MDR-TB) treatment regimen in a previous placebo-controlled, phase 2 trial (…

The usefulness of isoniazid (INH), a key component of short-course chemotherapy of
tuberculosis, is threatened by the emergence of drug-resistant strains of Mycobacterium …

Multidrug-resistant tuberculosis (MDR-TB), caused by drug-resistant strains of Mycobacterium
tuberculosis, is an increasingly serious problem worldwide. Here we examined a data set …

Understanding the ecology of drug-resistant pathogens is essential for devising rational
programs to preserve the effective lifespan of antimicrobial agents and to abrogate epidemics of …

Mycobacteria, such as the etiological agent of human tuberculosis, Mycobacterium
tuberculosis, are protected by an impermeable cell envelope composed of an inner cytoplasmic …

Background The continued advance of antibiotic resistance threatens the treatment and
control of many infectious diseases. This is exemplified by the largest global outbreak of …

Beijing/W strains of Mycobacterium tuberculosis are geographically widespread and
hypervirulent. To enhance our understanding of their origin and evolution, we sought …