Genome Sequence of Aedes aegypti, a Major Arbovirus Vector

…, S Wyder, Q Zeng, Q Zhao, Y Zhao, CA Hill, AS Raikhel… - Science, 2007 - science.org
We present a draft sequence of the genome of Aedes aegypti, the primary vector for yellow
fever and dengue fever, which at ∼1376 million base pairs is about 5 times the size of the …

Accumulation of yolk proteins in insect oocytes

AS Raikhel, TS Dhadialla - Annual review of entomology, 1992 - annualreviews.org
In insects, accumulation of yolk, or vitellogenesis, is a heterosynthetic proн cess, in which an
extraovarian tissue, the fat body, produces yolk protein precursors (1, 92). Heterosynthetic …

Evolutionary dynamics of immune-related genes and pathways in disease-vector mosquitoes

…, W Wei, L Zheng, Z Zou, DW Severson, AS Raikhel… - science, 2007 - science.org
Mosquitoes are vectors of parasitic and viral diseases of immense importance for public
health. The acquisition of the genome sequence of the yellow fever and Dengue vector, Aedes …

Molecular characteristics of insect vitellogenins and vitellogenin receptors

TW Sappington, AS Raikhel - Insect biochemistry and molecular biology, 1998 - Elsevier
The recent cloning and sequencing of several insect vitellogenins (Vg), the major yolk protein
precursor of most oviparous animals, and the mosquito Vg receptor (VgR) has brought the …

Sequencing of Culex quinquefasciatus Establishes a Platform for Mosquito Comparative Genomics

…, D Lawson, NH Lee, MAT Muskavitch, AS Raikhel… - Science, 2010 - science.org
Culex quinquefasciatus (the southern house mosquito) is an important mosquito vector of
viruses such as West Nile virus and St. Louis encephalitis virus, as well as of nematodes that …

Wolbachia induces reactive oxygen species (ROS)-dependent activation of the Toll pathway to control dengue virus in the mosquito Aedes aegypti

…, J Wu, G Bian, P Lu, AS Raikhel… - Proceedings of the …, 2012 - National Acad Sciences
Wolbachia are maternally transmitted symbiotic bacteria that can spread within insect
populations because of their unique ability to manipulate host reproduction. When introduced to …

[HTML][HTML] Improved reference genome of Aedes aegypti informs arbovirus vector control

…, CA Hill, JS Johnston, TD Murphy, AS Raikhel… - Nature, 2018 - nature.com
Female Aedes aegypti mosquitoes infect more than 400 million people each year with
dangerous viral pathogens including dengue, yellow fever, Zika and chikungunya. Progress in …

Regulatory pathways controlling female insect reproduction

…, TT Saha, Z Zou, AS Raikhel - Annual Review of …, 2018 - annualreviews.org
The synthesis of vitellogenin and its uptake by maturing oocytes during egg maturation are
essential for successful female reproduction. These events are regulated by the juvenile …

Nutritional regulation of vitellogenesis in mosquitoes: implications for anautogeny

GM Attardo, IA Hansen, AS Raikhel - Insect biochemistry and molecular …, 2005 - Elsevier
Anautogeny is a successful reproductive strategy utilized by many mosquito species and other
disease-transmitting arthropod vectors. Developing an understanding of the mechanisms …

Molecular biology of mosquito vitellogenesis: from basic studies to genetic engineering of antipathogen immunity

AS Raikhel, VA Kokoza, J Zhu, D Martin… - Insect biochemistry and …, 2002 - Elsevier
Elucidation of molecular mechanisms underlying stage- and tissue-specific expression of
genes activated by a blood meal is of great importance for current efforts directed towards …