User profiles for Alexander Shapson-Coe
Alexander Shapson-CoeQueen Mary, University of London Verified email at qmul.ac.uk Cited by 372 |
A connectomic study of a petascale fragment of human cerebral cortex
We acquired a rapidly preserved human surgical sample from the temporal lobe of the cerebral
cortex. We stained a 1 mm 3 volume with heavy metals, embedded it in resin, cut more …
cortex. We stained a 1 mm 3 volume with heavy metals, embedded it in resin, cut more …
[HTML][HTML] Connectome 2.0: Developing the next-generation ultra-high gradient strength human MRI scanner for bridging studies of the micro-, meso-and macro …
…, J Augustinack, D Berger, A Shapson-Coe… - Neuroimage, 2021 - Elsevier
The first phase of the Human Connectome Project pioneered advances in MRI technology
for mapping the macroscopic structural connections of the living human brain through the …
for mapping the macroscopic structural connections of the living human brain through the …
Mapping of neuronal and glial primary cilia contactome and connectome in the human cerebral cortex
JY Wu, SJ Cho, K Descant, PH Li, A Shapson-Coe… - Neuron, 2024 - cell.com
Primary cilia act as antenna receivers of environmental signals and enable effective neuronal
or glial responses. Disruption of their function is associated with circuit disorders. To …
or glial responses. Disruption of their function is associated with circuit disorders. To …
[HTML][HTML] A comparison of parenteral phenobarbital vs. parenteral phenytoin as second-line management for pediatric convulsive status epilepticus in a resource …
RJ Burman, S Ackermann, A Shapson-Coe… - Frontiers in …, 2019 - frontiersin.org
Introduction: Pediatric convulsive status epilepticus (CSE) which is refractory to first-line
benzodiazepines is a significant clinical challenge, especially within resource-limited countries. …
benzodiazepines is a significant clinical challenge, especially within resource-limited countries. …
Moyamoya syndrome in South African children with HIV-1 infection
CK Hammond, A Shapson-Coe… - Journal of child …, 2016 - journals.sagepub.com
A national multicenter study identified 17 South African children with vertically acquired HIV-1
infection and HIV-associated vasculopathy. Five of the children (all indigenous African …
infection and HIV-associated vasculopathy. Five of the children (all indigenous African …
[HTML][HTML] Vitamin D abnormalities and bone turn over analysis in children with epilepsy in the Western Cape of South Africa.
E Kija, BE Gidal, A Shapson-Coe, S Cader… - Seizure, 2019 - Elsevier
Purpose: The effects of antiseizure medications (ASMs) on bone metabolism is inconsistent.
Most studies are in high income settings and none from sub-Saharan Africa. Methods: A …
Most studies are in high income settings and none from sub-Saharan Africa. Methods: A …
[HTML][HTML] Aicardi–Goutières Syndrome associated mutations of RNase H2B impair its interaction with ZMYM3 and the CoREST histone-modifying complex
A Shapson-Coe, B Valeiras, C Wall, C Rada - Plos one, 2019 - journals.plos.org
DNA-RNA hybrids arise in all cell types, and are removed by multiple enzymes, including
the trimeric ribonuclease, RNase H2. Mutations in human RNase H2 result in Aicardi–…
the trimeric ribonuclease, RNase H2. Mutations in human RNase H2 result in Aicardi–…
Denoising-based image compression for connectomics
Connectomic reconstruction of neural circuits relies on nanometer resolution microscopy
which produces on the order of a petabyte of imagery for each cubic millimeter of brain tissue. …
which produces on the order of a petabyte of imagery for each cubic millimeter of brain tissue. …
Edited by: Introduction: Pediatric convulsive status epilepticus (CSE) which is refractory to first-line benzodiazepines is a significant clinical challenge, especially within …
…, S Ackermann, A Shapson-Coe… - … Editor's Pick 2021, 2021 - books.google.com
Purpose: This study aimed to compare the use of parenteral phenobarbital against parenteral
phenytoin as a second-line agent in the management of pediatric CSE. Methodology: An …
phenytoin as a second-line agent in the management of pediatric CSE. Methodology: An …
Studies of the MYM-type zinc finger protein ZMYM3
A Shapson-Coe - 2024 - repository.cam.ac.uk
RNase H2 is a trimeric ribonuclease that specifically degrades the RNA moiety of DNARNA
hybrids. Mutations in RNase H2 result in Aicardi–Goutières syndrome (AGS), a rare …
hybrids. Mutations in RNase H2 result in Aicardi–Goutières syndrome (AGS), a rare …