The endoplasmic reticulum (ER) is the main site of protein and lipid synthesis, membrane
biogenesis, xenobiotic detoxification and cellular calcium storage, and perturbation of ER …

Extracellular vesicles (EVs), through their complex cargo, can reflect the state of their cell of
origin and change the functions and phenotypes of other cells. These features indicate …

Despite decades of accumulated knowledge about proteins and their post-translational
modifications (PTMs), numerous questions remain regarding their molecular composition and …

Extracellular vesicles (EVs) are phospholipid bilayer membrane-enclosed structures containing
RNAs, proteins, lipids, metabolites, and other molecules, secreted by various cells into …

Humans and mice infected with different Plasmodium strains are known to produce microvesicles
derived from the infected red blood cells (RBCs), denoted RMVs. Studies in mice have …

Respiratory viruses cause infections of the upper or lower respiratory tract and they are
responsible for the common cold—the most prevalent disease in the world. In many cases the …

Importance Coronary computed tomographic angiography (coronary CTA) can characterize
coronary artery disease, including high-risk plaque. A noninvasive method of identifying high…

Mounting an effective host immune response without incurring inflammatory injury requires
the precise regulation of cytokine expression 1 , 2 . To achieve this, cytokine mRNAs are post-…

It is generally acknowledged that reactive oxygen species (ROS) play crucial roles in a
variety of natural processes in cells. If increased to levels which cannot be neutralized by the …

Analyzing proteins from single cells by tandem mass spectrometry (MS) has recently become
technically feasible. While such analysis has the potential to accurately quantify thousands …