CD4 + CD25 + regulatory T cells are essential for the active suppression of autoimmunity.
Here we report that the forkhead transcription factor Foxp3 is specifically expressed in CD4 + …

… We thank all members of the Rudensky lab for advice and discussions; and K. Forbush, L.
Hsing, Y. Liang and L. Karpik for technical expertise and mouse colony management. …

Regulatory CD4 + T cells (T r cells), the development of which is critically dependent on X-linked
transcription factor Foxp3 (forkhead box P3), prevent self-destructive immune …

A balance between pro- and anti-inflammatory mechanisms at mucosal interfaces, which are
sites of constitutive exposure to microbes and non-microbial foreign substances, allows for …

T helper cells that produce IL-17 (T H 17 cells) promote autoimmunity in mice and have been
implicated in the pathogenesis of human inflammatory diseases. At mucosal surfaces, T H …

Regulatory T cell-mediated dominant tolerance has been demonstrated to play an important
role in the prevention of autoimmunity. Here, we present data arguing that the forkhead …

Immune homeostasis is dependent on tight control over the size of a population of regulatory
T (T reg ) cells capable of suppressing over-exuberant immune responses. The T reg cell …

Peptide:MHC II complexes derived from a fluorescent antigen were detected in vivo to
identify the cells that present subcutaneously injected antigen to CD4 T cells. Skin-derived …

Intestinal microbes provide multicellular hosts with nutrients and confer resistance to infection.
The delicate balance between pro- and anti-inflammatory mechanisms, essential for gut …

The regulatory T (Treg) cells restrain immune responses through suppressor-function
elaboration that is dependent upon expression of the transcription factor Foxp3. Despite a critical …