The continual evolution of SARS-CoV-2 and the emergence of variants that show resistance
to vaccines and neutralizing antibodies threaten to prolong the COVID-19 pandemic. …

The adaptive immune system recognizes antigens via an immense array of antigen-binding
antibodies and T-cell receptors, the immune repertoire. The interrogation of immune …

The mechanisms underlying the chronicity of autoimmune diseases of the central nervous
system (CNS) are largely unknown. In particular, it is unclear whether tissue-resident memory …

Increasing evidence suggests that antibody-drug conjugates (ADCs) can enhance anti-tumor
immunity and improve clinical outcome. Here, we elucidate the therapeutic efficacy and …

In chronic inflammatory diseases of the central nervous system (CNS), immune cells persisting
behind the blood-brain barrier are supposed to promulgate local tissue destruction. The …

B- and T-cell receptor repertoires of the adaptive immune system have become a key target
for diagnostics and therapeutics research. Consequently, there is a rapidly growing number …

Existing approaches to therapeutic gene transfer are marred by the transient nature of gene
expression following non-integrative gene delivery and by safety concerns due to the …

COVID-19 disease outcome is highly dependent on adaptive immunity from T and B
lymphocytes, which play a critical role in the control, clearance and long-term protection against …

Asymmetric partitioning of fate determinants is a mechanism that contributes to T cell
differentiation. However, it remains unclear whether the ability of T cells to divide asymmetrically is …

Cytomegalovirus-based vaccine vectors offer interesting opportunities for T cell-based
vaccination purposes as CMV infection induces large numbers of functional effector-like cells that …