Fibrosis is characterized by the excessive extracellular matrix deposition due to dysregulated
wound and connective tissue repair response. Multiple organs can develop fibrosis, …

Persistent inflammation within the respiratory tract underlies the pathogenesis of numerous
chronic pulmonary diseases including chronic obstructive pulmonary disease, asthma and …

Pemetrexed represents the first antifolate cancer drug to be approved by the Food and Drug
Administration in 20 years; it is currently in widespread use for first line therapy of …

Disclosures: DJ Nolan reported personal fees from Angiocrine Bioscience outside the
submitted work; in addition, DJ Nolan had a patent number 8,465,732 issued (Angiocrine …

The chemotherapeutic drug pemetrexed, an inhibitor of thymidylate synthase, has an important
secondary target in human leukemic cells, aminoimidazolecarboxamide ribonucleotide …

Vascular injury is a well-established, disease-modifying factor in acute respiratory distress
syndrome (ARDS) pathogenesis. Recently, coronavirus disease 2019 (COVID-19)–induced …

As antimicrobial resistance increases, understanding the current epidemiology of bloodstream
infections (BSIs) in hematopoietic stem cell transplant (HSCT) recipients is essential to …

The lymphatic vasculature is critical for lung function, but defects in lymphatic function in the
pathogenesis of lung disease is understudied. In mice, lymphatic dysfunction alone is …

The development of chronic lung disease occurs as a consequence of multiple cellular events
that involve an initial insult which often leads to the development of chronic inflammation, …

The coronavirus disease-19 (COVID-19) pandemic has ravaged global healthcare with
previously unseen levels of morbidity and mortality. In this study, we performed large-scale …