Adipogenesis and metabolic health
AL Ghaben, PE Scherer - Nature reviews Molecular cell biology, 2019 - nature.com
Obesity is characterized by increased adipose tissue mass and has been associated with a
strong predisposition towards metabolic diseases and cancer. Thus, it constitutes a public …
strong predisposition towards metabolic diseases and cancer. Thus, it constitutes a public …
[PDF][PDF] Extracellular vesicle-based interorgan transport of mitochondria from energetically stressed adipocytes
Adipocytes undergo intense energetic stress in obesity resulting in loss of mitochondrial
mass and function. We have found that adipocytes respond to mitochondrial stress by rapidly …
mass and function. We have found that adipocytes respond to mitochondrial stress by rapidly …
Identification of functionally distinct fibro-inflammatory and adipogenic stromal subpopulations in visceral adipose tissue of adult mice
10.7554/eLife.39636.001 White adipose tissue (WAT) remodeling is dictated by coordinated
interactions between adipocytes and resident stromal-vascular cells; however, the …
interactions between adipocytes and resident stromal-vascular cells; however, the …
[HTML][HTML] Dermal adipose tissue has high plasticity and undergoes reversible dedifferentiation in mice
Dermal adipose tissue (also known as dermal white adipose tissue and herein referred to
as dWAT) has been the focus of much discussion in recent years. However, dWAT remains …
as dWAT) has been the focus of much discussion in recent years. However, dWAT remains …
[PDF][PDF] Adipocyte iron levels impinge on a fat-gut crosstalk to regulate intestinal lipid absorption and mediate protection from obesity
Iron overload is positively associated with diabetes risk. However, the role of iron in adipose
tissue remains incompletely understood. Here, we report that transferrin-receptor-1-…
tissue remains incompletely understood. Here, we report that transferrin-receptor-1-…
[HTML][HTML] Human endotrophin as a driver of malignant tumor growth
D Bu, C Crewe, CM Kusminski, R Gordillo, AL Ghaben… - JCI insight, 2019 - ncbi.nlm.nih.gov
We have previously reported that the carboxy-terminal proteolytic cleavage product of the
COL6α3 chain that we refer to as “endotrophin” has potent effects on transformed mammary …
COL6α3 chain that we refer to as “endotrophin” has potent effects on transformed mammary …
[HTML][HTML] SREBP-regulated adipocyte lipogenesis is dependent on substrate availability and redox modulation of mTORC1
The synthesis of lipid and sterol species through de novo lipogenesis (DNL) is regulated by
2 functionally overlapping but distinct transcription factors: the SREBPs and carbohydrate …
2 functionally overlapping but distinct transcription factors: the SREBPs and carbohydrate …
[HTML][HTML] Acute loss of adipose tissue-derived adiponectin triggers immediate metabolic deterioration in mice
Aim/hypothesis Adiponectin (APN), a circulating hormone secreted by mature adipocytes,
has been extensively studied because it has beneficial metabolic effects. While many studies …
has been extensively studied because it has beneficial metabolic effects. While many studies …
A novel model of diabetic complications: adipocyte mitochondrial dysfunction triggers massive β-cell hyperplasia
CM Kusminski, AL Ghaben, TS Morley, RJ Samms… - Diabetes, 2020 - Am Diabetes Assoc
Obesity-associated type 2 diabetes mellitus (T2DM) entails insulin resistance and loss of β-cell
mass. Adipose tissue mitochondrial dysfunction is emerging as a key component in the …
mass. Adipose tissue mitochondrial dysfunction is emerging as a key component in the …
Directing visceral white adipocyte precursors to a thermogenic adipocyte fate improves insulin sensitivity in obese mice
10.7554/eLife.27669.001 Visceral adiposity confers significant risk for developing metabolic
disease in obesity whereas preferential expansion of subcutaneous white adipose tissue (…
disease in obesity whereas preferential expansion of subcutaneous white adipose tissue (…