User profiles for Alexandra K Walker
 | Alexandra K WalkerResearch Fellow, Birmingham University Verified email at bham.ac.uk Cited by 530 |
Isomerization of BRCA1–BARD1 promotes replication fork protection
The integrity of genomes is constantly threatened by problems encountered by the replication
fork. BRCA1, BRCA2 and a subset of Fanconi anaemia proteins protect stalled replication …
fork. BRCA1, BRCA2 and a subset of Fanconi anaemia proteins protect stalled replication …
[HTML][HTML] PrimPol-dependent single-stranded gap formation mediates homologous recombination at bulky DNA adducts
Stalled replication forks can be restarted and repaired by RAD51-mediated homologous
recombination (HR), but HR can also perform post-replicative repair after bypass of the obstacle…
recombination (HR), but HR can also perform post-replicative repair after bypass of the obstacle…
Impact of PNKP mutations associated with microcephaly, seizures and developmental delay on enzyme activity and DNA strand break repair
JJ Reynolds, AK Walker, EC Gilmore… - Nucleic acids …, 2012 - academic.oup.com
Microcephaly with early-onset, intractable seizures and developmental delay (MCSZ) is a
hereditary disease caused by mutations in polynucleotide kinase/phosphatase (PNKP), a DNA …
hereditary disease caused by mutations in polynucleotide kinase/phosphatase (PNKP), a DNA …
The deSUMOylase SENP2 coordinates homologous recombination and nonhomologous end joining by independent mechanisms
SUMOylation (small ubiquitin-like modifier) in the DNA double-strand break (DSB) response
regulates recruitment, activity, and clearance of repair factors. However, our understanding …
regulates recruitment, activity, and clearance of repair factors. However, our understanding …
[HTML][HTML] MRE11 as a predictive biomarker of outcome after radiation therapy in bladder cancer
AK Walker, K Karaszi, H Valentine, VY Strauss… - International Journal of …, 2019 - Elsevier
Purpose Organ-confined muscle-invasive bladder cancer is treated with cystectomy or bladder
preservation techniques, including radiation therapy. There are currently no biomarkers …
preservation techniques, including radiation therapy. There are currently no biomarkers …
[HTML][HTML] Harnessing citizen science through mobile phone technology to screen for immunohistochemical biomarkers in bladder cancer
Background Immunohistochemistry (IHC) is often used in personalisation of cancer
treatments. Analysis of large data sets to uncover predictive biomarkers by specialists can be …
treatments. Analysis of large data sets to uncover predictive biomarkers by specialists can be …
[HTML][HTML] No additional prognostic value for MRE11 in squamous cell carcinomas of the anus treated with chemo-radiotherapy
AK Walker, C Kartsonaki, E Collantes… - British journal of …, 2017 - nature.com
Background: The majority of anal cancers (84–95%) are driven by infection with human
papillomavirus (HPV). HPV-positive tumours show significantly better responses to chemo-…
papillomavirus (HPV). HPV-positive tumours show significantly better responses to chemo-…
USP50 suppresses alternative RecQ helicase use and deleterious DNA2 activity during replication.
…, RM Densham, SH Reed, F Dobbs, AK Walker… - bioRxiv, 2024 - biorxiv.org
Mammalian DNA replication employs several RecQ DNA helicases to orchestrate the
faithful duplication of genetic information. Helicase function is often coupled to the activity of …
faithful duplication of genetic information. Helicase function is often coupled to the activity of …
[HTML][HTML] MRE11A isoform expression associated with outcome following radiotherapy in muscle-invasive bladder cancer does not alter cell survival and DNA Double …
Background: DNA double strand breaks are the cytotoxic lesions produced by ionising
radiation. Critical for the repair of these lesions is the DNA damage response protein MRE11 …
radiation. Critical for the repair of these lesions is the DNA damage response protein MRE11 …
Modification of the SUMO activating enzyme subunit SAE2 directs SUMO isoform bias required for mitotic fidelity
Protein conjugation with the Small Ubiquitin-like Modifier SUMO1 or the related SUMO2/3
drive changes to protein behaviour. Many substrates are found modified by both SUMO1 and …
drive changes to protein behaviour. Many substrates are found modified by both SUMO1 and …