Combining theory, model, and experiment to explain how intrinsic theta rhythms are generated in an in vitro whole hippocampus preparation without oscillatory inputs

KA Ferguson, AP Chatzikalymniou, FK Skinner - eneuro, 2017 - eneuro.org
Scientists have observed local field potential theta rhythms (3–12 Hz) in the hippocampus for
decades, but understanding the mechanisms underlying their generation is complicated by …

Deciphering the contribution of oriens-lacunosum/moleculare (OLM) cells to intrinsic θ rhythms using biophysical local field potential (LFP) models

AP Chatzikalymniou, FK Skinner - Eneuro, 2018 - eneuro.org
Oscillations in local field potentials (LFPs) are prevalent and contribute to brain function. An
understanding of the cellular correlates and pathways affecting LFPs is needed, but many …

[HTML][HTML] A hypothesis for theta rhythm frequency control in CA1 microcircuits

…, AR Lunyov, J Lefebvre, AP Chatzikalymniou - Frontiers in neural …, 2021 - frontiersin.org
Computational models of neural circuits with varying levels of biophysical detail have been
generated in pursuit of an underlying mechanism explaining the ubiquitous hippocampal …

Linking minimal and detailed models of CA1 microcircuits reveals how theta rhythms emerge and how their frequencies are controlled

AP Chatzikalymniou, M Gumus, AR Lunyov, S Rich… - bioRxiv, 2020 - biorxiv.org
The wide variety of cell types and their inherent biophysical complexities pose a challenge to
our understanding of oscillatory activities produced by cellular-based computational models…

Cholecystokinin-expressing (CCK+) basket cells are key controllers of theta-gamma coupled rhythms in the hippocampus

AP Chatzikalymniou, S Sengupta, J Lefebvre… - bioRxiv, 2022 - biorxiv.org
It has been shown that different inhibitory cell types underlie brain rhythmic and cross-frequency
coupling output, but exactly how inhibitory cell types manifest their contributions to these …

Linking minimal and detailed models of CA1 microcircuits reveals how theta rhythms emerge and their frequencies controlled

AP Chatzikalymniou, M Gumus, FK Skinner - Hippocampus, 2021 - Wiley Online Library
The wide variety of cell types and their biophysical complexities pose a challenge in our
ability to understand oscillatory activities produced by cellular‐based computational network …

Oscillatory Dynamics of Brain Microcircuits: Modeling Perspectives and Neurological Disease Considerations

FK Skinner, AP Chatzikalymniou - Computational Models of …, 2017 - Wiley Online Library
We describe two previously presented approaches to modeling oscillations in brain microcircuits
in which multiple levels of organization and cellular perspectives are considered. We …

Combining theory, model and experiment to understand how theta rhythms are generated in the hippocampus

KA Ferguson, AP Chatzikalymniou, FK Skinner - bioRxiv, 2017 - biorxiv.org
Scientists have observed theta rhythms (3–12 Hz) in the hippocampus for decades, but we
do not have a clear understanding of how they are generated. This is largely due to the …

Towards a general framework for modeling large-scale biophysical neuronal networks: a full-scale computational model of the rat dentate gyrus

…, C Schneider, D Hadjiabadi, A Chatzikalymniou… - bioRxiv, 2021 - biorxiv.org
Large-scale computational models of the brain are necessary to accurately represent
anatomical and functional variability in neuronal biophysics across brain regions and also to …

[BOOK][B] On the generation of theta rhythms in the hippocampus

A Chatzikalymniou - 2021 - search.proquest.com
A prevalent local field potential (LFP) rhythm in the CA1 hippocampus associated with
memory processing and spatial navigation is the (3-12 Hz) theta oscillation. Theta rhythms …