Transforming growth factor β (TGF-β) plays an important role in normal development and
homeostasis. Dysregulation of TGF-β responsiveness and its downstream signaling pathways …

Enzalutamide, a second-generation small-molecule inhibitor of the androgen receptor (AR),
has been approved for patients who failed with androgen deprivation therapy and have …

We have developed a mouse DNA methylation array that contains 296,070 probes representing
the diversity of mouse DNA methylation biology. We present a mouse methylation atlas …

Women experience osteoporosis at higher rates than men. Aside from hormones, the
mechanisms driving sex-dependent bone mass regulation are not well understood. Here, we …

TGF-β plays a central role in prostate cancer (PCa) bone metastasis, and it is crucial to
understand the bone cell–specific role of TGF-β signaling in this process. Thus, we used …

Metabolic programming of the innate immune cells known as dendritic cells (DCs) changes
in response to different stimuli, influencing their function. While the mechanisms behind …

Enzalutamide resistance has been observed in approximately 50% of patients with prostate
cancer (PCa) bone metastases. Therefore, there is an urgent need to investigate the …

The role of myeloid cell-specific TGF-β signaling in non-small-cell lung cancer (NSCLC)-induced
osteolytic bone lesion development is unknown. We used a genetically engineered …

Prostate cancer (PCa) is one of the most diagnosed cancers in American men and is a leading
cause of cancer deaths in advanced forms of disease. Seventy to ninety percent of men …

The functional and phenotypic heterogeneity of dendritic cells (DCs) plays a crucial role in
facilitating the development of diverse immune responses that are essential for providing host …