Noonan syndrome (NS), the most common among RASopathies, is caused by germline
variants in genes encoding components of the RAS-MAPK pathway. Distinct variants, including …

Background Brugada syndrome (BrS) is causing sudden cardiac death (SCD) mainly at young
age. Studying the underlying mechanisms associated with BrS type I electrocardiogram (…

Patients harboring causative gene variants in RAS GTPase MRAS develop Noonan syndrome
and early-onset hypertrophic cardiomyopathy. Here, we describe the generation of a …

Noonan syndrome (NS), the most common among the RASopathies, is caused by germline
variants in genes encoding components of the RAS-MAPK pathway. Distinct variants, …

Noonan syndrome patients harboring causative variants in LZTR1 are particularly at risk to
develop severe and early-onset hypertrophic cardiomyopathy. However, the underling …

Activating KRAS codon 12 gene variants are known to cause severe RAS-MAPK and PI3K-AKT
signaling pathway hyperactivity and are frequently involved in the development of …

Noonan syndrome (NS) is a multisystemic disorder that is known as one of the most common
monogenetic diseases associated with early-onset congenital heart defects, such as …

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… Married 13 March, 1879, HRH Princess Louise Margaret Alexandra Victoria Agnes of Prussia
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