Many different solutions to predicting the cognate epitope target of a T-cell receptor (TCR)
have been proposed. However several questions on the advantages and disadvantages of …

T-cell–based diagnostic tools identify pathogen exposure but lack differentiation between
recent and historical exposures in acute infectious diseases. Here, T-cell receptor (TCR) RNA …

Background COVID-19 patients experience several features of dysregulated immune
system observed in sepsis. We previously showed a dysregulation of several proline-selective …

Coronavirus disease 2019 (COVID-19) is a viral lower respiratory tract infection caused by
the highly transmissible and pathogenic SARS-CoV-2 (severe acute respiratory-syndrome …

Despite the general agreement on the significance of T cells during SARS-CoV-2 infection,
the clinical impact of specific and cross-reactive T-cell responses remains uncertain. …

Gut microbes can profoundly modulate mucosal barrier-promoting Th17 cells in mammals. A
salient feature of HIV/simian immunodeficiency virus (SIV) immunopathogenesis is the loss …

INTRODUCTION The microbiota promotes the maturation and homeostasis of the immune
system, in part through the release of microbial products. Early-life microbial colonization has …

Increased mortality in antiretroviral (ARV)-treated, HIV-infected individuals has been
attributed to persistent immune dysfunction, in part due to abnormalities at the gastrointestinal …

Intestinal microbial dysbiosis has been described in individuals with an HIV-1 infection and
may underlie persistent inflammation in chronic infection, thereby contributing to disease …

We report a pleiotropic disease due to loss-of-function mutations in RHBDF2, the gene
encoding iRHOM2, in two kindreds with recurrent infections in different organs. One patient had …