A major challenge in human genetics is to devise a systematic strategy to integrate disease-associated
variants with diverse genomic and biological data sets to provide insight into …

Human gut microbiome composition is shaped by multiple factors but the relative contribution
of host genetics remains elusive. Here we examine genotype and microbiome data from …

Fecal microbiome variation in the average, healthy population has remained under-investigated.
Here, we analyzed two independent, extensively phenotyped cohorts: the Belgian …

Identifying the downstream effects of disease-associated SNPs is challenging. To help
overcome this problem, we performed expression quantitative trait locus (eQTL) meta-analysis in …

The inflammatory bowel diseases (IBDs), which include Crohn’s disease (CD) and ulcerative
colitis (UC), are multifactorial chronic conditions of the gastrointestinal tract. While IBD has …

Deep sequencing of the gut microbiomes of 1135 participants from a Dutch population-based
cohort shows relations between the microbiome and 126 exogenous and intrinsic host …

To study the effect of host genetics on gut microbiome composition, the MiBioGen consortium
curated and analyzed genome-wide genotypes and 16S fecal microbiome data from …

To identify new genetic risk factors for rheumatoid arthritis, we conducted a genome-wide
association study meta-analysis of 5,539 autoantibody-positive individuals with rheumatoid …

The relationship between gut microbial metabolism and mental health is one of the most
intriguing and controversial topics in microbiome research. Bidirectional microbiota–gut–brain …

We performed a second-generation genome-wide association study of 4,533 individuals with
celiac disease (cases) and 10,750 control subjects. We genotyped 113 selected SNPs with …