Single-cell RNA-seq reveals new types of human blood dendritic cells, monocytes, and progenitors
AC Villani, R Satija, G Reynolds, S Sarkizova… - Science, 2017 - science.org
INTRODUCTION Dendritic cells (DCs) and monocytes consist of multiple specialized
subtypes that play a central role in pathogen sensing, phagocytosis, and antigen presentation. …
subtypes that play a central role in pathogen sensing, phagocytosis, and antigen presentation. …
Common variants in the NLRP3 region contribute to Crohn's disease susceptibility
AC Villani, M Lemire, G Fortin, E Louis, MS Silverberg… - Nature …, 2009 - nature.com
We used a candidate gene approach to identify a set of SNPs, located in a predicted regulatory
region on chromosome 1q44 downstream of NLRP3 (previously known as CIAS1 and …
region on chromosome 1q44 downstream of NLRP3 (previously known as CIAS1 and …
Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq
…, SW Kazer, A Gaillard, KE Kolb, AC Villani… - Science, 2016 - science.org
To explore the distinct genotypic and phenotypic states of melanoma tumors, we applied
single-cell RNA sequencing (RNA-seq) to 4645 single cells isolated from 19 patients, profiling …
single-cell RNA sequencing (RNA-seq) to 4645 single cells isolated from 19 patients, profiling …
[PDF][PDF] Defining T cell states associated with response to checkpoint immunotherapy in melanoma
Treatment of cancer has been revolutionized by immune checkpoint blockade therapies.
Despite the high rate of response in advanced melanoma, the majority of patients succumb to …
Despite the high rate of response in advanced melanoma, the majority of patients succumb to …
[HTML][HTML] COVID-19 tissue atlases reveal SARS-CoV-2 pathology and cellular targets
COVID-19, which is caused by SARS-CoV-2, can result in acute respiratory distress syndrome
and multiple organ failure 1 , 2 , 3 – 4 , but little is known about its pathophysiology. Here …
and multiple organ failure 1 , 2 , 3 – 4 , but little is known about its pathophysiology. Here …
Viral epitope profiling of COVID-19 patients reveals cross-reactivity and correlates of severity
…, AC Villani… - Science, 2020 - science.org
INTRODUCTION A systematic characterization of the humoral response to severe acute
respiratory system coronavirus 2 (SARS-CoV-2) epitopes has yet to be performed. This analysis …
respiratory system coronavirus 2 (SARS-CoV-2) epitopes has yet to be performed. This analysis …
Systematic comparison of single-cell and single-nucleus RNA-sequencing methods
…, O Rozenblatt-Rosen, AK Shalek, AC Villani… - Nature …, 2020 - nature.com
The scale and capabilities of single-cell RNA-sequencing methods have expanded rapidly
in recent years, enabling major discoveries and large-scale cell mapping efforts. However, …
in recent years, enabling major discoveries and large-scale cell mapping efforts. However, …
[PDF][PDF] Intra-and inter-cellular rewiring of the human colon during ulcerative colitis
…, J Yao, C Stevens, D Dionne, LT Nguyen, AC Villani… - Cell, 2019 - cell.com
Genome-wide association studies (GWAS) have revealed risk alleles for ulcerative colitis (UC).
To understand their cell type specificities and pathways of action, we generate an atlas of …
To understand their cell type specificities and pathways of action, we generate an atlas of …
[HTML][HTML] Landscape of X chromosome inactivation across human tissues
X chromosome inactivation (XCI) silences transcription from one of the two X chromosomes
in female mammalian cells to balance expression dosage between XX females and XY …
in female mammalian cells to balance expression dosage between XX females and XY …
Common genetic variants modulate pathogen-sensing responses in human dendritic cells
Introduction Variation in an individual’s response to environmental factors is likely to influence
susceptibility to complex human diseases. The genetic basis of such variation is poorly …
susceptibility to complex human diseases. The genetic basis of such variation is poorly …