The proneural transcription factor Ascl1 coordinates gene expression in both proliferating
and differentiating progenitors along the neuronal lineage. Here, we used a cellular model of …

Mutants in the actin nucleators Cappuccino and Spire disrupt the polarized microtubule
network in the Drosophila oocyte that defines the anterior-posterior axis, suggesting that …

Centrosome asymmetry plays a key role in ensuring the asymmetric division of Drosophila
neural stem cells (neuroblasts [NBs]) and male germline stem cells (GSCs) [1–3]. In both …

10.7554/eLife.12717.001 In the developing mammalian brain, differentiating neurons mature
morphologically via neuronal polarity programs. Despite discovery of polarity pathways …

Citrullination, the deimination of peptidylarginine residues into peptidylcitrulline, has been
implicated in the etiology of several diseases. In multiple sclerosis, citrullination is thought to …

The generation of neurons from neural stem cells requires large-scale changes in gene
expression that are controlled to a large extent by proneural transcription factors, such as Ascl1. …

Glioblastoma is the most common and aggressive brain tumor, with a subpopulation of stem‐like
cells thought to mediate its recurring behavior and therapeutic resistance. The epithelial…

The modification of neuronal connections in response to stimuli is believed to be the basis
of long-term memory formation. It is currently accepted that local protein synthesis critically …

Neurons of the mammalian neocortex are produced by proliferating cells located in the
ventricular zone (VZ) lining the lateral ventricles. This is a complex and sequential process, …

The spinal cord dorsal horn is a major station for integration and relay of somatosensory
information and comprises both excitatory and inhibitory neuronal populations. The homeobox …