Genome-wide epigenetic regulation by early-life trauma

…, L Navaro, V Yerko, I Mahar, A Bureau… - Archives of general …, 2012 - jamanetwork.com
Context Our genome adapts to environmental influences, in part through epigenetic
mechanisms, including DNA methylation. Variations in the quality of the early environment are …

Impulsive-aggressive behaviours and completed suicide across the life cycle: a predisposition for younger age of suicide

A McGirr, J Renaud, A Bureau, M Seguin… - Psychological …, 2008 - cambridge.org
BackgroundIt is unclear whether the association between impulsive-aggressive behaviours
and suicide exists across different ages.MethodVia psychological autopsy, we examined a …

Identifying SNPs predictive of phenotype using random forests

A Bureau, J Dupuis, K Falls, KL Lunetta… - … Official Publication of …, 2005 - Wiley Online Library
There has been a great interest and a few successes in the identification of complex disease
susceptibility genes in recent years. Association studies, where a large number of single‐…

Applications of continuous time hidden Markov models to the study of misclassified disease outcomes

A Bureau, S Shiboski, JP Hughes - Statistics in medicine, 2003 - Wiley Online Library
Disease progression in prospective clinical and epidemiological studies is often conceptualized
in terms of transitions between disease states. Analysis of data from such studies can be …

[PDF][PDF] Homozygous deletion of the very low density lipoprotein receptor gene causes autosomal recessive cerebellar hypoplasia with cerebral gyral simplification

KM Boycott, S Flavelle, A Bureau, HC Glass… - The American Journal of …, 2005 - cell.com
An autosomal recessive syndrome of nonprogressive cerebellar ataxia and mental retardation
is associated with inferior cerebellar hypoplasia and mild cerebral gyral simplification in …

Whole exome sequencing of distant relatives in multiplex families implicates rare variants in candidate genes for oral clefts

A Bureau, MM Parker, I Ruczinski, MA Taub… - Genetics, 2014 - academic.oup.com
A dozen genes/regions have been confirmed as genetic risk factors for oral clefts in human
association and linkage studies, and animal models argue even more genes may be involved…

Differences and similarities in the serotonergic diathesis for suicide attempts and mood disorders: a 22-year longitudinal gene–environment study

J Brezo, A Bureau, C Mérette, V Jomphe… - Molecular …, 2010 - nature.com
To investigate similarities and differences in the serotonergic diathesis for mood disorders
and suicide attempts, we conducted a study in a cohort followed longitudinally for 22 years. A …

A genome‐wide association study of suicidal behavior

…, I Giegling, D Rujescu, A Bureau… - American Journal of …, 2015 - Wiley Online Library
Genome wide array studies have reported limited success in identifying genetic markers
conferring risk for suicidal behavior (SB). This may be attributable to study designs with primary …

An assessment of gene‐by‐environment interactions in developmental dyslexia‐related phenotypes

S Mascheretti, A Bureau, M Battaglia… - Genes, Brain and …, 2013 - Wiley Online Library
While the genetic and environmental contributions to developmental dyslexia ( DD ) have
been studied extensively, the effects of identified genetic risk susceptibility and of specified …

[HTML][HTML] Mapping complex traits using Random Forests

A Bureau, J Dupuis, B Hayward, K Falls… - BMC genetics, 2003 - Springer
Random Forest is a prediction technique based on growing trees on bootstrap samples of
data, in conjunction with a random selection of explanatory variables to define the best split at …