User profiles for Alexandre Pellan Cheng
 | Alexandre Pellan ChengNew York Genome Center, Weill Cornell Medical College Verified email at nygenome.org Cited by 392 |
[PDF][PDF] Cell-free DNA tissues of origin by methylation profiling reveals significant cell, tissue, and organ-specific injury related to COVID-19 severity
Background Coronavirus disease 2019 (COVID-19) primarily affects the lungs, but evidence
of systemic disease with multi-organ involvement is emerging. Here, we developed a blood …
of systemic disease with multi-organ involvement is emerging. Here, we developed a blood …
Cell-free DNA profiling informs all major complications of hematopoietic cell transplantation
Allogeneic hematopoietic cell transplantation (HCT) provides effective treatment for
hematologic malignancies and immune disorders. Monitoring of posttransplant complications is …
hematologic malignancies and immune disorders. Monitoring of posttransplant complications is …
[HTML][HTML] A metagenomic DNA sequencing assay that is robust against environmental DNA contamination
Metagenomic DNA sequencing is a powerful tool to characterize microbial communities but
is sensitive to environmental DNA contamination, in particular when applied to samples with …
is sensitive to environmental DNA contamination, in particular when applied to samples with …
A cell-free DNA metagenomic sequencing assay that integrates the host injury response to infection
High-throughput metagenomic sequencing offers an unbiased approach to identify pathogens
in clinical samples. Conventional metagenomic sequencing, however, does not integrate …
in clinical samples. Conventional metagenomic sequencing, however, does not integrate …
[HTML][HTML] Separating the signal from the noise in metagenomic cell-free DNA sequencing
Background Cell-free DNA (cfDNA) in blood, urine, and other biofluids provides a unique
window into human health. A proportion of cfDNA is derived from bacteria and viruses, creating …
window into human health. A proportion of cfDNA is derived from bacteria and viruses, creating …
Machine learning guided signal enrichment for ultrasensitive plasma tumor burden monitoring
In solid tumor oncology, circulating tumor DNA (ctDNA) is poised to transform care through
accurate assessment of minimal residual disease (MRD) and therapeutic response monitoring…
accurate assessment of minimal residual disease (MRD) and therapeutic response monitoring…
[HTML][HTML] Cell-free DNA in blood reveals significant cell, tissue and organ specific injury and predicts COVID-19 severity
COVID-19 primarily affects the lungs, but evidence of systemic disease with multi-organ
involvement is emerging. Here, we developed a blood test to broadly quantify cell, tissue, and …
involvement is emerging. Here, we developed a blood test to broadly quantify cell, tissue, and …
Whole genome error-corrected sequencing for sensitive circulating tumor DNA cancer monitoring
Circulating cell-free DNA (ccfDNA) sequencing for low-burden cancer monitoring is limited
by sparsity of circulating tumor DNA (ctDNA), the abundance of genomic material within a …
by sparsity of circulating tumor DNA (ctDNA), the abundance of genomic material within a …
Biopsy‐free screening for glioma
Circulating tumor DNA (ctDNA) is a promising diagnostic marker for many cancers and can
be noninvasively assayed from blood. For diagnosing glioma, this approach has …
be noninvasively assayed from blood. For diagnosing glioma, this approach has …
[PDF][PDF] Cell-free DNA Tissues-of-Origin Profiling to Predict Graft versus Host Disease and Detect Infection after Hematopoietic Cell Transplantation
16 17 ABSTRACT: Allogeneic hematopoietic cell transplantation (HCT) provides effective
treatment for 18 hematologic malignancies and immune disorders. Monitoring for immune …
treatment for 18 hematologic malignancies and immune disorders. Monitoring for immune …