In the mammalian CNS, each neuron typically receives thousands of synaptic inputs from
diverse classes of neurons. Synaptic transmission to the postsynaptic neuron relies on …

The development of neural circuits relies on axon projections establishing diverse, yet well-defined,
connections between areas of the nervous system. Each projection is formed by …

Transmembrane proteins BRI2 and amyloid precursor protein (APP) co-localize with amyloid
β (Aβ) lesions in sporadic Alzheimer disease and mutations in both precursor proteins are …

The postsynaptic adhesion protein neuroligin-2 (NL2) is selectively localized at inhibitory
synapses. Here, we studied network activity in the dentate gyrus of NL2-deficient mice …

The formation of neuronal synapses and the dynamic regulation of their efficacy depend on
the assembly of the postsynaptic neurotransmitter receptor apparatus. Receptor recruitment …

Neuroligins are postsynaptic adhesion proteins involved in the establishment of functional
synapses in the central nervous system. In rodents, four genes give rise to neuroligins that …

Transcriptomic approaches are powerful strategies to map the molecular diversity of cells in
the brain. Single-cell genomic atlases have now been compiled for entire mammalian brains…

The claustrum is a narrow subcortical brain structure that resides between the striatum and
insular cortex. The function of the claustrum is not fully described, and while our previous …

During neuronal development, growth cones (GCs) of projection neurons navigate complex
extracellular environments to reach distant targets, thereby generating extraordinarily …

Cas9 targets genomic loci with high specificity. For knockin with double-strand break repair,
however, Cas9 often leads to unintended on-target knockout rather than intended edits. This …