A genome-wide association study with 1,126,563 individuals identifies new risk loci for Alzheimer's disease
Late-onset Alzheimer’s disease is a prevalent age-related polygenic disease that accounts
for 50–70% of dementia cases. Currently, only a fraction of the genetic variants underlying …
for 50–70% of dementia cases. Currently, only a fraction of the genetic variants underlying …
[HTML][HTML] Understanding the genetic determinants of the brain with MOSTest
Regional brain morphology has a complex genetic architecture, consisting of many common
polymorphisms with small individual effects. This has proven challenging for genome-wide …
polymorphisms with small individual effects. This has proven challenging for genome-wide …
Common brain disorders are associated with heritable patterns of apparent aging of the brain
Common risk factors for psychiatric and other brain disorders are likely to converge on biological
pathways influencing the development and maintenance of brain structure and function …
pathways influencing the development and maintenance of brain structure and function …
[HTML][HTML] Genetic overlap between Alzheimer's disease and bipolar disorder implicates the MARK2 and VAC14 genes
OK Drange, OB Smeland, AA Shadrin… - Frontiers in …, 2019 - frontiersin.org
Background: Alzheimer’s disease (AD) and bipolar disorder (BIP) are complex traits influenced
by numerous common genetic variants, most of which remain to be detected. Clinical and …
by numerous common genetic variants, most of which remain to be detected. Clinical and …
[HTML][HTML] The genetic architecture of human brainstem structures and their involvement in common brain disorders
Brainstem regions support vital bodily functions, yet their genetic architectures and involvement
in common brain disorders remain understudied. Here, using imaging-genetics data …
in common brain disorders remain understudied. Here, using imaging-genetics data …
[HTML][HTML] Bivariate causal mixture model quantifies polygenic overlap between complex traits beyond genetic correlation
Accumulating evidence from genome wide association studies (GWAS) suggests an
abundance of shared genetic influences among complex human traits and disorders, such as …
abundance of shared genetic influences among complex human traits and disorders, such as …
[HTML][HTML] Beyond SNP heritability: Polygenicity and discoverability of phenotypes estimated with a univariate Gaussian mixture model
Estimating the polygenicity (proportion of causally associated single nucleotide polymorphisms
(SNPs)) and discoverability (effect size variance) of causal SNPs for human traits is …
(SNPs)) and discoverability (effect size variance) of causal SNPs for human traits is …
[HTML][HTML] Vertex-wise multivariate genome-wide association study identifies 780 unique genetic loci associated with cortical morphology
Brain morphology has been shown to be highly heritable, yet only a small portion of the
heritability is explained by the genetic variants discovered so far. Here we extended the …
heritability is explained by the genetic variants discovered so far. Here we extended the …
Multivariate genetic analysis of personality and cognitive traits reveals abundant pleiotropy
G Hindley, AA Shadrin, D van der Meer… - Nature human …, 2023 - nature.com
Personality and cognitive function are heritable mental traits whose genetic foundations may
be distributed across interconnected brain functions. Previous studies have typically treated …
be distributed across interconnected brain functions. Previous studies have typically treated …
Genetic association between schizophrenia and cortical brain surface area and thickness
…, KS O'Connell, Y Chu, S Bahrami, AA Shadrin… - JAMA …, 2021 - jamanetwork.com
Importance Schizophrenia is a complex heritable disorder associated with many genetic
variants, each with a small effect. While cortical differences between patients with schizophrenia …
variants, each with a small effect. While cortical differences between patients with schizophrenia …