Biophysical characterization of the underappreciated and important relationship between heart rate variability and heart rate
O Monfredi, AE Lyashkov, AB Johnsen, S Inada… - …, 2014 - Am Heart Assoc
Heart rate (HR) variability (HRV; beat-to-beat changes in the R-wave to R-wave interval) has
attracted considerable attention during the past 30+ years (PubMed currently lists >17 000 …
attracted considerable attention during the past 30+ years (PubMed currently lists >17 000 …
High Basal Protein Kinase A–Dependent Phosphorylation Drives Rhythmic Internal Ca2+ Store Oscillations and Spontaneous Beating of Cardiac Pacemaker Cells
TM Vinogradova, AE Lyashkov, W Zhu… - Circulation …, 2006 - Am Heart Assoc
Local, rhythmic, subsarcolemmal Ca 2+ releases (LCRs) from the sarcoplasmic reticulum (SR)
during diastolic depolarization in sinoatrial nodal cells (SANC) occur even in the basal …
during diastolic depolarization in sinoatrial nodal cells (SANC) occur even in the basal …
Rhythmic Ryanodine Receptor Ca2+ Releases During Diastolic Depolarization of Sinoatrial Pacemaker Cells Do Not Require Membrane Depolarization
…, YY Zhou, V Maltsev, A Lyashkov… - Circulation …, 2004 - Am Heart Assoc
Localized, subsarcolemmal Ca 2+ release (LCR) via ryanodine receptors (RyRs) during
diastolic depolarization of sinoatrial nodal cells augments the terminal depolarization rate. We …
diastolic depolarization of sinoatrial nodal cells augments the terminal depolarization rate. We …
Discovery proteomics in aging human skeletal muscle finds change in spliceosome, immunity, proteostasis and mitochondria
C Ubaida-Mohien, A Lyashkov, M Gonzalez-Freire… - Elife, 2019 - elifesciences.org
10.7554/eLife.49874.001 A decline of skeletal muscle strength with aging is a primary cause
of mobility loss and frailty in older persons, but the molecular mechanisms of such decline …
of mobility loss and frailty in older persons, but the molecular mechanisms of such decline …
[HTML][HTML] Skeletal muscle transcriptome in healthy aging
…, M Kaileh, LM Zukley, CW Chia, A Lyashkov… - Nature …, 2021 - nature.com
Age-associated changes in gene expression in skeletal muscle of healthy individuals reflect
accumulation of damage and compensatory adaptations to preserve tissue integrity. To …
accumulation of damage and compensatory adaptations to preserve tissue integrity. To …
Proteomics in aging research: A roadmap to clinical, translational research
…, C Ubaida‐Mohien, T Tanaka, A Lyashkov… - Aging …, 2021 - Wiley Online Library
The identification of plasma proteins that systematically change with age and, independent
of chronological age, predict accelerated decline of health is an expanding area of research. …
of chronological age, predict accelerated decline of health is an expanding area of research. …
Membrane Potential Fluctuations Resulting From Submembrane Ca2+ Releases in Rabbit Sinoatrial Nodal Cells Impart an Exponential Phase to the Late Diastolic …
…, VA Maltsev, TM Vinogradova, AE Lyashkov… - Circulation …, 2006 - Am Heart Assoc
Stochastic but roughly periodic LCRs (Local subsarcolemmal ryanodine receptor–mediated
Ca 2+ Releases) during the late phase of diastolic depolarization (DD) in rabbit sinoatrial …
Ca 2+ Releases) during the late phase of diastolic depolarization (DD) in rabbit sinoatrial …
[HTML][HTML] Ca2+-stimulated basal adenylyl cyclase activity localization in membrane lipid microdomains of cardiac sinoatrial nodal pacemaker cells
A Younes, AE Lyashkov, D Graham, A Sheydina… - Journal of biological …, 2008 - ASBMB
Spontaneous, rhythmic subsarcolemmal local Ca 2+ releases driven by cAMP-mediated,
protein kinase A (PKA)-dependent phosphorylation are crucial for normal pacemaker function …
protein kinase A (PKA)-dependent phosphorylation are crucial for normal pacemaker function …
Calcium cycling protein density and functional importance to automaticity of isolated sinoatrial nodal cells are independent of cell size
AE Lyashkov, M Juhaszova, H Dobrzynski… - Circulation …, 2007 - Am Heart Assoc
Spontaneous, localized, rhythmic ryanodine receptor (RyRs) Ca 2+ releases occur beneath
the cell membrane during late diastolic depolarization in cardiac sinoatrial nodal cells (…
the cell membrane during late diastolic depolarization in cardiac sinoatrial nodal cells (…
Constitutive Phosphodiesterase Activity Restricts Spontaneous Beating Rate of Cardiac Pacemaker Cells by Suppressing Local Ca2+ Releases
TM Vinogradova, S Sirenko, AE Lyashkov… - Circulation …, 2008 - Am Heart Assoc
Spontaneous beating of rabbit sinoatrial node cells (SANCs) is controlled by cAMP-mediated,
protein kinase A–dependent local subsarcolemmal ryanodine receptor Ca 2+ releases (…
protein kinase A–dependent local subsarcolemmal ryanodine receptor Ca 2+ releases (…