User profiles for Alexis Brice
alexis briceICM Verified email at icm-institute.org Cited by 127885 |
Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease
…, P Passmore, TJ Montine, K Bettens, JI Rotter, A Brice… - Nature …, 2013 - nature.com
Eleven susceptibility loci for late-onset Alzheimer's disease (LOAD) were identified by previous
studies; however, a large portion of the genetic risk for this disease remains unexplained. …
studies; however, a large portion of the genetic risk for this disease remains unexplained. …
Mutations in the DJ-1 Gene Associated with Autosomal Recessive Early-Onset Parkinsonism
…, JW van Dongen, N Vanacore, JC van Swieten, A Brice… - Science, 2003 - science.org
The DJ-1 gene encodes a ubiquitous, highly conserved protein. Here, we show that DJ-1
mutations are associated with PARK7, a monogenic form of human parkinsonism. The function …
mutations are associated with PARK7, a monogenic form of human parkinsonism. The function …
Friedreich's ataxia: autosomal recessive disease caused by an intronic GAA triplet repeat expansion
…, H Koutnikova, SI Bidichandani, C Gellera, A Brice… - Science, 1996 - science.org
Friedreich's ataxia (FRDA) is an autosomal recessive, degenerative disease that involves
the central and peripheral nervous systems and the heart. A gene, X25, was identified in the …
the central and peripheral nervous systems and the heart. A gene, X25, was identified in the …
[HTML][HTML] Multicenter analysis of glucocerebrosidase mutations in Parkinson's disease
Background Recent studies indicate an increased frequency of mutations in the gene
encoding glucocerebrosidase (GBA), a deficiency of which causes Gaucher's disease, among …
encoding glucocerebrosidase (GBA), a deficiency of which causes Gaucher's disease, among …
Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease
We conducted a meta-analysis of Parkinson's disease genome-wide association studies
using a common set of 7,893,274 variants across 13,708 cases and 95,282 controls. Twenty-six …
using a common set of 7,893,274 variants across 13,708 cases and 95,282 controls. Twenty-six …
[HTML][HTML] Association between Early-Onset Parkinson's Disease and Mutations in the Parkin Gene
Background Mutations in the parkin gene have recently been identified in patients with early-onset
Parkinson's disease, but the frequency of the mutations and the associated …
Parkinson's disease, but the frequency of the mutations and the associated …
[HTML][HTML] Phenotype, genotype, and worldwide genetic penetrance of LRRK2-associated Parkinson's disease: a case-control study
Background Mutations in LRRK2, the gene that encodes leucine-rich repeat kinase 2, are a
cause of Parkinson's disease (PD). The International LRRK2 Consortium was established to …
cause of Parkinson's disease (PD). The International LRRK2 Consortium was established to …
Identification of novel risk loci, causal insights, and heritable risk for Parkinson's disease: a meta-analysis of genome-wide association studies
Background Genome-wide association studies (GWAS) in Parkinson's disease have increased
the scope of biological knowledge about the disease over the past decade. We aimed to …
the scope of biological knowledge about the disease over the past decade. We aimed to …
APP locus duplication causes autosomal dominant early-onset Alzheimer disease with cerebral amyloid angiopathy
…, A Vital, C Dumanchin, S Feuillette, A Brice… - Nature …, 2006 - nature.com
We report duplication of the APP locus on chromosome 21 in five families with autosomal
dominant early-onset Alzheimer disease (ADEOAD) and cerebral amyloid angiopathy (CAA). …
dominant early-onset Alzheimer disease (ADEOAD) and cerebral amyloid angiopathy (CAA). …
Parkinson's disease: from monogenic forms to genetic susceptibility factors
S Lesage, A Brice - Human molecular genetics, 2009 - academic.oup.com
Research in Parkinson's disease (PD) genetics has been extremely prolific over the past
decade. More than 13 loci and 9 genes have been identified, but their implication in PD is not …
decade. More than 13 loci and 9 genes have been identified, but their implication in PD is not …