Isolated nociceptors reveal multiple specializations for generating irregular ongoing activity associated with ongoing pain
MA Odem, AG Bavencoffe, RM Cassidy, ER Lopez… - Pain, 2018 - journals.lww.com
Ongoing pain has been linked to ongoing activity (OA) in human C-fiber nociceptors, but rodent
models of pain-related OA have concentrated on allodynia rather than ongoing pain, and …
models of pain-related OA have concentrated on allodynia rather than ongoing pain, and …
[HTML][HTML] EPAC1 and EPAC2 promote nociceptor hyperactivity associated with chronic pain after spinal cord injury
Chronic pain following spinal cord injury (SCI) is associated with electrical hyperactivity (spontaneous
and evoked) in primary nociceptors. Cyclic adenosine monophosphate (cAMP) …
and evoked) in primary nociceptors. Cyclic adenosine monophosphate (cAMP) …
Readiness of nociceptor cell bodies to generate spontaneous activity results from background activity of diverse ion channels and high input resistance
Nociceptor cell bodies generate “spontaneous” discharge that can promote ongoing pain in
persistent pain conditions. Little is known about the underlying mechanisms. Recordings …
persistent pain conditions. Little is known about the underlying mechanisms. Recordings …
Widespread latent hyperactivity of nociceptors outlasts enhanced avoidance behavior following incision injury
AG Bavencoffe, ER Lopez, KN Johnson, J Tian… - bioRxiv, 2024 - biorxiv.org
Nociceptors with somata in dorsal root ganglia (DRGs) exhibit an unusual readiness to
switch from an electrically silent state to a hyperactive state of tonic, nonaccommodating, low-…
switch from an electrically silent state to a hyperactive state of tonic, nonaccommodating, low-…
Frequency-independent biological signal identification (FIBSI): A free program that simplifies intensive analysis of non-stationary time series data
RM Cassidy, AG Bavencoffe, ER Lopez, SS Cheruvu… - bioRxiv, 2020 - biorxiv.org
Extracting biological signals from non-linear, dynamic and stochastic experimental data can
be challenging, especially when the signal is non-stationary. Many currently available …
be challenging, especially when the signal is non-stationary. Many currently available …
Macrophage migration inhibitory factor (MIF) makes complex contributions to pain-related hyperactivity of nociceptors after spinal cord injury
A Bavencoffe, EA Spence, MY Zhu… - Journal of …, 2022 - Soc Neuroscience
… The minimum weight of the rats included in this study was 320 g, which was large enough
to minimize chances for paws going between the probes. All trials were captured in 1080p at …
to minimize chances for paws going between the probes. All trials were captured in 1080p at …
[PDF][PDF] EPAC1 and EPAC2 promote nociceptor hyperactivity
…, X Cheng, ET Walters, CW Dessauer, AG Bavencoffe - 2019 - researchgate.net
Chronic pain following spinal cord injury (SCI) is associated with electrical hyperactivity (spontaneous
and evoked) in primary nociceptors. Cyclic adenosine monophosphate (cAMP) …
and evoked) in primary nociceptors. Cyclic adenosine monophosphate (cAMP) …
[HTML][HTML] The transient receptor potential channel TRPM8 is inhibited via the α2A adrenoreceptor signaling pathway
… cells, employment of specific pharmacological and molecular tools combined with patch-clamp
recording of the whole-cell TRPM8 currents, we show that this effect is mediated via G i …
recording of the whole-cell TRPM8 currents, we show that this effect is mediated via G i …
Interleukin-10 resolves pain hypersensitivity induced by cisplatin by reversing sensory neuron hyperexcitability
G Laumet, A Bavencoffe, JD Edralin, XJ Huo… - Pain, 2020 - journals.lww.com
Understanding the mechanisms that drive transition from acute to chronic pain is essential to
identify new therapeutic targets. The importance of endogenous resolution pathways acting …
identify new therapeutic targets. The importance of endogenous resolution pathways acting …
Persistent electrical activity in primary nociceptors after spinal cord injury is maintained by scaffolded adenylyl cyclase and protein kinase A and is associated with …
A Bavencoffe, Y Li, Z Wu, Q Yang… - Journal of …, 2016 - Soc Neuroscience
Little is known about intracellular signaling mechanisms that persistently excite neurons in
pain pathways. Persistent spontaneous activity (SA) generated in the cell bodies of primary …
pain pathways. Persistent spontaneous activity (SA) generated in the cell bodies of primary …