The gene encoding the Aurora-A protein kinase is located in the 20q13 breast cancer amplicon
and is also overexpressed in colorectal, pancreatic and gastric tumours. Although Aurora…

Following DNA damage caused by exogenous sources, such as ionizing radiation, the
tumour suppressor p53 mediates cell cycle arrest via expression of the CDK inhibitor, p21. …

Autosomal recessive primary microcephaly (MCPH) is characterized by a substantial
reduction in prenatal human brain growth without alteration of the cerebral architecture and is …

Purpose: Triple-negative breast cancer (TNBC) is a heterogeneous subgroup of breast
cancer that is associated with a poor prognosis. We evaluated the activity of CDK4/6 inhibitors …

The way in which cells adopt different morphologies is not fully understood. Cell shape could
be a continuous variable or restricted to a set of discrete forms. We developed quantitative …

Endothelial cells line the blood and lymphatic vasculature, and act as an essential physical
barrier, control nutrient transport, facilitate tissue immunosurveillance and coordinate …

The transition from G1 into DNA replication (S phase) is an emergent behavior resulting
from dynamic and complex interactions between cyclin-dependent kinases (Cdks), Cdk …

Loss-of-function (LOF) methods such as RNA interference (RNAi), antisense oligonucleotides
or CRISPR-based genome editing provide unparalleled power for studying the biological …

The centrosomal protein, CDK5RAP2, is mutated in primary microcephaly, a
neurodevelopmental disorder characterized by reduced brain size. The Drosophila melanogaster …

A key step in homologous recombination is the loading of Rad51 onto single-stranded DNA
to form a nucleoprotein filament that promotes homologous DNA pairing and strand …