Integrin-mediated adhesion is known to stimulate production of phosphatidylinositol4, 5-bisphosphate(4,
5-PIP*) and increase 4, 5-PIP2 hydrolysis in response to platelet-derived …

Inositol (l,4,5)trisphosphate (InsP 3 ) 1 and tetrakisphosphate (InsP 4 ) 2 have been
observed in a variety of cell types and have been proposed to play roles in the receptor-mediated …

The Rac GTP-binding proteins are members of the Rho family and regulate growth factor-stimulated
actin assembly in a variety of cells. The formation of phosphorylated inositol lipids …

OSMOREGULATION, inhibitory neurotransmission and pH balance depend on chloride ion (Cl
− ) flux. In intestinal epithelial cells, apical Cl − channels control salt and fluid secretion …

Phosphoinositides are rapidly turning-over phospholipids that play key roles in intracellular
signaling and modulation of membrane effectors. Through technical refinements we have …

Endoplasmic reticulum–plasma membrane (ER–PM) contact sites play an integral role in
cellular processes such as excitation–contraction coupling and store-operated calcium entry (…

This study examined whether epidermal growth factor (EGF) inhibits Ca(2+)-dependent Cl-
secretion by T84 cells. Basolateral EGF inhibited Cl- secretion induced by carbachol or …

Neutrophils contain a multicomponent NADPH oxidase system that is involved in the
production of microbicidal oxidants. Stimulation of human neutrophils with the peptide FMLP …

Phosphoinositide 3-OH kinases and their products, D-3 phosphorylated phosphoinositides,
are increasingly recognized as crucial elements in many signaling cascades. A reliable …

Myo-inositol is an important cellular osmolyte in autoregulation of cell volume and fluid
balance, particularly for mammalian brain and kidney cells. We find it also regulates excitability. …