Proliferative chronic myelomonocytic leukemia (pCMML), an aggressive CMML subtype, is
associated with dismal outcomes. RAS pathway mutations, mainly NRAS G12D , define the …

Chronic myelomonocytic leukemia (CMML) and juvenile myelomonocytic leukemia (JMML)
are myelodysplastic syndrome (MDS)/myeloproliferative neoplasm (MPN) overlap disorders …

Mutations in chromatin regulator ASXL1 are frequently identified in myeloid malignancies,
in particular ∼40% of patients with chronic myelomonocytic leukemia (CMML). ASXL1 …

Casitas B-lineage lymphoma (CBL) encodes an E3 ubiquitin ligase and signaling adaptor
that regulates receptor and nonreceptor tyrosine kinases. Recurrent CBL mutations occur in …

Alterations in epigenetic control are a hallmark of AML. This study establishes that a MYC–TFEB
circuit controls AML differentiation and epigenetic programs by inducing IDH1/IDH2 and …

NLRP3 inflammasome and IFN-stimulated gene (ISG) induction are key biological drivers of
ineffective hematopoiesis and inflammation in myelodysplastic syndromes (MDSs). Gene …

Modeling chronic myelomonocytic leukemia (CMML) in immunodeficient NSGS mice relies
on unique human CMML specimens and consistent murine engraftment. Only anecdotal …

Purpose: Preclinical studies in myeloid neoplasms have demonstrated efficacy of bromodomain
and extra-terminal protein inhibitors (BETi). However, BETi demonstrates poor single-…

Ten Eleven Translocation 2 (TET2) is a dioxygenase which regulates gene expression by
oxidizing 5-methylcytosine to 5-hydroxymethylcytosine. Loss of function mutations in TET2 …

Chronic myelomonocytic leukemia (CMML) is an aggressive hematological malignancy with
limited treatment options. Whole exome (WES) and targeted sequencing of several …