The death of a cell is an inevitable part of its biology. During homeostasis, most cells die
through apoptosis. If homeostasis is disturbed, cell death can switch to proinflammatory forms of …

10.7554/eLife.24437.001 Neutrophils release neutrophil extracellular traps (NETs) which
ensnare pathogens and have pathogenic functions in diverse diseases. We examined the …

Despite the fundamental role of canonical histones in nucleosome structure, there is no
experimental system for higher eukaryotes in which basic questions about histone function can …

The relation of α‐synuclein (αS) aggregation to Parkinson's disease (PD) has long been
recognized, but the mechanism of toxicity, the pathogenic species and its molecular properties …

Although many metazoan enzymes that add or remove specific modifications on histone
proteins are essential transcriptional regulators, the functional significance of posttranslational …

Entry into S phase of the mitotic cell cycle is normally strictly dependent on progression through
the preceding M phase. In contrast, during endoreduplication, which accompanies post-…

10.7554/eLife.15567.001 Despite remarkable developments in diffraction unlimited super-resolution
microscopy, in vivo nanoscopy of tissues and model organisms is still not …

10.7554/eLife.02443.001 Eukaryotes package DNA into nucleosomes that contain a core of
histone proteins. During DNA replication, nucleosomes are disrupted and re-assembled …

Drosophila PIM and THR are required for sister chromatid separation in mitosis and associate
in vivo. Neither of these two proteins shares significant sequence similarity with known …

Drosophila Pimples (PIM) and Three rows (THR) are required for sister chromatid separation
in mitosis. PIM accumulates during interphase and is degraded rapidly during mitosis. This …