Peroxynitrite promotes oxidative damage and is implicated in the pathophysiology of
various diseases that involve accelerated rates of nitric oxide and superoxide formation. The …

With the advent of new and improved high-throughput sequencing technologies in the last few
years, a growing number of novel classes of small RNA, other than miRNAs or siRNA, has …

In a recently published study, Anna Krichevsky and colleagues raise the important question
of whether results of in vitro extracellular RNA (exRNA) studies, including extracellular …

Peroxynitrite (ONOO−) is a potent oxidizing and nitrating agent produced by the reaction of
nitric oxide with superoxide. It readily nitrates phenolic compounds such as tyrosine residues …

Intercellular communication can be mediated by extracellular small regulatory RNAs (sRNAs).
Circulating sRNAs are being intensively studied for their promising use as minimally …

Extracellular vesicles (EVs), namely, exosomes and microvesicles, are important mediators
of intercellular communication pathways. Since EVs can be detected in a variety of biofluids …

The protozoan parasite Trypanosoma cruzi has a complex life cycle characterized by intracellular
and extracellular forms alternating between invertebrate and mammals. To cope with …

At present, noncoding small RNAs are recognized as key players in novel forms of
posttranscriptional gene regulation in most eukaryotes. However, canonical small RNA pathways …

The report that exogenous plant miRNAs are able to cross the mammalian gastrointestinal
tract and exert gene-regulation mechanism in mammalian tissues has yielded a lot of …

Over the last years an expanding family of small RNAs (ie microRNAs, siRNAs and piRNAs)
was recognized as key players in diverse forms of gene silencing and chromatin …