User profiles for Alfonso Valencia
 | Alfonso ValenciaICREA Professor. Barcelona Supercomputing Center. Verified email at bsc.es Cited by 90650 |
The ras protein family: evolutionary tree and role of conserved amino acids
A Valencia, P Chardin, A Wittinghofer, C Sander - Biochemistry, 1991 - ACS Publications
The early discovery of ras genes was due to their highly oncogenic potential when transduced
in retroviruses, such as the Harvey and Kirsten murine sarcoma viruses containing viral …
in retroviruses, such as the Harvey and Kirsten murine sarcoma viruses containing viral …
Computational methods for the prediction of protein interactions
A Valencia, F Pazos - Current opinion in structural biology, 2002 - Elsevier
Establishing protein interaction networks is crucial for understanding cellular operations.
Detailed knowledge of the ‘interactome’, the full network of protein–protein interactions, in …
Detailed knowledge of the ‘interactome’, the full network of protein–protein interactions, in …
[HTML][HTML] Towards FAIR principles for research software
The FAIR Guiding Principles, published in 2016, aim to improve the findability, accessibility,
interoperability and reusability of digital research objects for both humans and machines. …
interoperability and reusability of digital research objects for both humans and machines. …
GENCODE: the reference human genome annotation for The ENCODE Project
The GENCODE Consortium aims to identify all gene features in the human genome using a
combination of computational analysis, manual annotation, and experimental validation. …
combination of computational analysis, manual annotation, and experimental validation. …
[HTML][HTML] Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia
Chronic lymphocytic leukaemia (CLL), the most frequent leukaemia in adults in Western
countries, is a heterogeneous disease with variable clinical presentation and evolution 1 , 2 . …
countries, is a heterogeneous disease with variable clinical presentation and evolution 1 , 2 . …
Exome sequencing identifies recurrent mutations of the splicing factor SF3B1 gene in chronic lymphocytic leukemia
Here we perform whole-exome sequencing of samples from 105 individuals with chronic
lymphocytic leukemia (CLL) 1 , 2 , the most frequent leukemia in adults in Western countries. …
lymphocytic leukemia (CLL) 1 , 2 , the most frequent leukemia in adults in Western countries. …
IntAct: an open source molecular interaction database
…, B Roechert, P Roepstorff, A Valencia… - Nucleic acids …, 2004 - academic.oup.com
IntAct provides an open source database and toolkit for the storage, presentation and
analysis of protein interactions. The web interface provides both textual and graphical …
analysis of protein interactions. The web interface provides both textual and graphical …
[PDF][PDF] The allelic landscape of human blood cell trait variation and links to common complex disease
Many common variants have been associated with hematological traits, but identification of
causal genes and pathways has proven challenging. We performed a genome-wide …
causal genes and pathways has proven challenging. We performed a genome-wide …
Correlated mutations and residue contacts in proteins
The maintenance of protein function and structure constrains the evolution of amino acid
sequences. This fact can be exploited to interpret correlated mutations observed in a sequence …
sequences. This fact can be exploited to interpret correlated mutations observed in a sequence …
An ATPase domain common to prokaryotic cell cycle proteins, sugar kinases, actin, and hsp70 heat shock proteins.
The functionally diverse actin, hexokinase, and hsp70 protein families have in common an
ATPase domain of known three-dimensional structure. Optimal superposition of the three …
ATPase domain of known three-dimensional structure. Optimal superposition of the three …