The three-dimensional structure of the complex between human H-Ras bound to guanosine
diphosphate and the guanosine triphosphatase (GTPase)–activating domain of the human …

The GTPase-activating protein (GAP) stimulates the GTPase reaction of p21 by 5 orders of
magnitude such that the k cat of the reaction is increased to 19 s-1. Mutations of residues in …

RAS-RELATED GTP-binding proteins function as molecular switches which cycle between
GTP-bound 'on'- and GDP-bound 'off'-states 1 . GTP hydrolysis is the common timing …

Stepwise degradation of the invariant chain (Ii) is required for the binding of antigenic
peptides to MHC class II molecules. Cathepsin (Cat) L in the murine thymus and Cat S in …

The effects of fatty acids and phospholipids on the interaction of the full‐length GTPase
activating protein (GAP) as well as its isolated C‐terminal domain and the Ha‐ras proto‐…

Revised Manuscript Received April 1, 1993 abstract: The three-dimensional structures and
biochemical properties of two mutants of the G-domain (residues 1-166) of p21H'ras, p21 (…

The asparagine-specific endoprotease (AEP) controls lysosomal processing of the potential
autoantigen myelin basic protein (MBP) by human B lymphoblastoid cells, a feature …

The kinetic properties for the enzymatic stimulation of the GTPase reaction of p21 ras by the
two GTPase-activating proteins (GAPs) p120 GAP and neurofibromin are different. In order …

Background and aims Alcoholic steatohepatitis (ASH)—the inflammation of fatty liver—is
caused by chronic alcohol consumption and represents one of the leading chronic liver …

Proteolysis by endocytic cysteine proteases is a central element of the antigen‐presentation
machinery in dendritic cells (DC). It controls the generation of immunogenic peptides, …