Host protein kinases required for SARS-CoV-2 nucleocapsid phosphorylation and viral replication
…, KN Burke, CE Hamele, RR Chaparian, AT Harding… - Science …, 2022 - science.org
Multiple coronaviruses have emerged independently in the past 20 years that cause lethal
human diseases. Although vaccine development targeting these viruses has been …
human diseases. Although vaccine development targeting these viruses has been …
[HTML][HTML] Efforts to improve the seasonal influenza vaccine
AT Harding, NS Heaton - Vaccines, 2018 - mdpi.com
Influenza viruses infect approximately 20% of the global population annually, resulting in
hundreds of thousands of deaths. While there are Food and Drug Administration (FDA) …
hundreds of thousands of deaths. While there are Food and Drug Administration (FDA) …
GPER1 is required to protect fetal health from maternal inflammation
Type I interferon (IFN) signaling in fetal tissues causes developmental abnormalities and
fetal demise. Although pathogens that infect fetal tissues can induce birth defects through the …
fetal demise. Although pathogens that infect fetal tissues can induce birth defects through the …
Control of antiviral innate immune response by protein geranylgeranylation
S Yang, AT Harding, C Sweeney, D Miao, G Swan… - Science …, 2019 - science.org
The mitochondrial antiviral signaling protein (MAVS) orchestrates host antiviral innate immune
response to RNA virus infection. However, how MAVS signaling is controlled to eradicate …
response to RNA virus infection. However, how MAVS signaling is controlled to eradicate …
[PDF][PDF] A CRISPR activation screen identifies a pan-avian influenza virus inhibitory host factor
BE Heaton, EM Kennedy, RE Dumm, AT Harding… - Cell reports, 2017 - cell.com
Influenza A virus (IAV) is a pathogen that poses significant risks to human health. It is therefore
critical to develop strategies to prevent influenza disease. Many loss-of-function screens …
critical to develop strategies to prevent influenza disease. Many loss-of-function screens …
[HTML][HTML] The impact of estrogens and their receptors on immunity and inflammation during infection
AT Harding, NS Heaton - Cancers, 2022 - mdpi.com
Simple Summary Human health is significantly affected by microbial infections. One of the
largest determinants of the outcomes of such infections is the host immune response. Too …
largest determinants of the outcomes of such infections is the host immune response. Too …
[PDF][PDF] Rapid tissue prototyping with micro-organospheres
…, M Negrete, H Yao, W Quayle, BE Heaton, AT Harding… - Stem cell reports, 2022 - cell.com
In vitro tissue models hold great promise for modeling diseases and drug responses. Here,
we used emulsion microfluidics to form micro-organospheres (MOSs), which are droplet-…
we used emulsion microfluidics to form micro-organospheres (MOSs), which are droplet-…
ETV7 limits antiviral gene expression and control of influenza viruses
HM Froggatt, AT Harding, RR Chaparian… - Science signaling, 2021 - science.org
The type I interferon (IFN) response is an important component of the innate immune
response to viral infection. Precise control of IFN responses is critical because insufficient …
response to viral infection. Precise control of IFN responses is critical because insufficient …
SRSF protein kinases 1 and 2 are essential host factors for human coronaviruses including SARS-CoV-2
…, KN Burke, CE Hamele, RR Chaparian, AT Harding… - 2020 - pesquisa.bvsalud.org
While vaccines are vital for preventing COVID-19 infections, it is critical to develop new
therapies to treat patients who become infected. Pharmacological targeting of a host factor …
therapies to treat patients who become infected. Pharmacological targeting of a host factor …
The FDA-approved drug Alectinib compromises SARS-CoV-2 nucleocapsid phosphorylation and inhibits viral infection in vitro
…, KN Burke, CE Hamele, RR Chaparian, AT Harding… - BioRxiv, 2020 - biorxiv.org
While vaccines are vital for preventing COVID-19 infections, it is critical to develop new
therapies to treat patients who become infected. Pharmacological targeting of a host factor …
therapies to treat patients who become infected. Pharmacological targeting of a host factor …