Hypertrophic cardiomyopathy (HCM) is a genetic disorder that is characterized by left
ventricular hypertrophy unexplained by secondary causes and a nondilated left ventricle with …

The novel coronavirus disease (COVID-19) outbreak, caused by SARS-CoV-2, represents the
greatest medical challenge in decades. We provide a comprehensive review of the clinical …

The approach to molecular genetic studies of complex phenotypes evolved considerably
during the recent years. The candidate gene approach, which is restricted to an analysis of a …

Arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVC) is a genetic disease
caused by mutations in desmosomal proteins. The phenotypic hallmark of ARVC is …

The vascular smooth muscle cell (SMC)-specific isoform of α-actin (ACTA2) is a major
component of the contractile apparatus in SMCs located throughout the arterial system. …

Background—Hypertrophic cardiomyopathy (HCM), the most common cause of sudden
cardiac death in the young, is characterized by cardiac hypertrophy, myocyte disarray, and …

Background Patients with nonobstructive hypertrophic cardiomyopathy (nHCM) often experience
a high burden of symptoms; however, there are no proven pharmacological therapies. …

High-density lipoprotein (HDL) protects against atherosclerosis. Endothelial lipase (EL) has
been postulated to be involved in lipoprotein, and possibly HDL, metabolism, yet the …

Background The variability of the phenotypic expression of left ventricular hypertrophy (LVH)
in patients with hypertrophic cardiomyopathy (HCM) indicates a potential role for additional …

Hypertrophic cardiomyopathy (HCM) is a genetic disorder caused by mutations in sarcomeric
proteins (excluding phenocopy). The causal genes in approximately one-third of the cases …