Background Genetic analysis has been successful in identifying causative mutations for
individual cardiovascular risk factors. Success has been more limited in mapping susceptibility …

McEvoy, MBBCh, MEHP, MHS, Assistant Professor of Medicine, Johns Hopkins Ciccarone
Center for the Prevention of Heart Disease, Division of Cardiology, Johns Hopkins University …

Body fat, insulin resistance, and type 2 diabetes are often linked together, but the molecular
mechanisms that unify their association are poorly understood. Wnt signaling regulates …

Vascular smooth muscle cell (VSMC) proliferation is an important event in atherosclerosis
and other vasculopathies. PDGF signaling is a key mediator of SMC proliferation, but the …

Aortopathies pose a significant healthcare burden due to excess early mortality, increasing
incidence, and underdiagnosis. Understanding the underlying genetic causes, early …

Whole-genome sequencing (WGS) was performed to identify the genetic determinants of
peanut allergy in the LEAP study participants (see the Methods section and Table E1 in this …

Platelet aggregation at the site of atherosclerotic vascular injury is the underlying pathophysiology
of myocardial infarction and stroke. To build upon prior GWAS, here we report on 16 …

Introduction Epicardial ablation is becoming an important part of management in patients
with ventricular tachycardia (VT). Posterior epicardial access via the Sosa or needle‐in‐needle …

Background Thoracic aortic aneurysms and dissections (TAAD) is a critical condition that
often goes undiagnosed with fatal consequences. While majority of the cases are sporadic, …

Coronary artery disease (CAD) remains a major cause of mortality and morbidity worldwide.
The aggregation of activated platelets on a ruptured atherosclerotic plaque is a critical step …