INTRODUCTION The nucleus harbors and protects the genetic information in eukaryotes. It
is surrounded by the nuclear envelope, which separates the nucleoplasm from the cytosol. …

Background The majority of human cancer deaths are caused by metastasis. The metastatic
dissemination is initiated by the breakdown of epithelial cell homeostasis. During this …

Abstract Changes in gene regulation underlie much of phenotypic evolution 1 . However,
our understanding of the potential for regulatory evolution is biased, because most evidence …

Subnuclear compartmentalization has been proposed to play an important role in gene
regulation by segregating active and inactive parts of the genome in distinct physical and …

Fibrosis can affect any organ, resulting in the loss of tissue architecture and function with often
life-threatening consequences. Pathologically, fibrosis is characterised by the expansion …

Background Initially detected in leukocytes and cancer cells derived from solid tissues, L-plastin/fimbrin
belongs to a large family of actin crosslinkers and is considered as a marker for …

Proteins that enter the secretory pathway are transported from their place of synthesis in the
endoplasmic reticulum to the Golgi complex by COPII-coated carriers. The networks of …

A significant challenge for developmental systems biology is balancing throughput with
controlled conditions that minimize experimental artifacts. Large-scale developmental screens …

Photosynthetic microalgae are responsible for an important fraction of CO 2 fixation and O 2
production on Earth. Three-dimensional (3D) ultrastructural characterization of these …

Faithful chromosome segregation during cell division requires accurate mitotic spindle
formation. As mitosis occurs rapidly within the cell cycle, the proteins involved in mitotic spindle …