Earlier, mapping of the 9p23–24 amplicon in esophageal cancer cell lines led us to the
positional cloning of gene amplified in squamous cell carcinoma 1 (GASC1), which encodes a …

Background: Despite more aggressive screening across all demographics and gradual
declines in mortality related to prostate cancer (PCa) in the United States, disparities among …

Gene amplification is a common mechanism of oncogene activation in cancer. Several large-scale
efforts aimed at identifying the comprehensive set of genomic regions that are …

Amplification of the 8p11-12 region has been found in about 15% of human breast cancers
and is associated with poor prognosis. Earlier, we used genomic analysis of copy number …

Background For breast cancer patients diagnosed with estrogen receptor (ER)-positive tumors,
treatment with tamoxifen is the gold standard. A significant number of patients, however, …

Despite more aggressive screening across all demographics and gradual declines in mortality
related to prostate cancer (PCa) in the United States, race disparities persist. For African …

Background Previous whole-genome shotgun bisulfite sequencing experiments showed
that DNA cytosine methylation in the honey bee (Apis mellifera) is almost exclusively at CG …

Among breast cancer patients, those diagnosed with the triple-negative breast cancer (TNBC)
subtype have the worst prog-nosis. TNBC does not express estrogen receptor-alpha, …

Background/Aim: African Americans (AA) have the highest incidence and mortality of any
racial/ethnic group in the US for most cancer types. Heterogeneity in the molecular biology of …

Background Enhanced glucose metabolism is a feature of most tumors, but downstream
functional effects of aberrant glucose flux are difficult to mechanistically determine. Metabolic …