Fibroblast activation protein-α (FAP) identifies stromal cells of mesenchymal origin in human
cancers and chronic inflammatory lesions. In mouse models of cancer, they have been …

In patients with cancer, the wasting syndrome, cachexia, is associated with caloric deficiency.
Here, we describe tumor-induced alterations of the host metabolic response to caloric …

The tumor microenvironment comprises a mass of heterogeneous cell types, including
immune cells, endothelial cells, and fibroblasts, alongside cancer cells. It is increasingly …

The magnitude and quality of the germinal center (GC) response decline with age, resulting
in poor vaccine-induced immunity in older individuals. A functional GC requires the co-…

The molecular mechanisms that regulate the rapid transcriptional changes that occur during
cytotoxic T lymphocyte (CTL) proliferation and differentiation in response to infection are …

Ectopic lymphoid structures form in a wide range of inflammatory conditions, including
infection, autoimmune disease, and cancer. In the context of infection, this response can be …

Fibroblastic reticular cells (FRCs), through their expression of CC chemokine ligand (CCL)19
and CCL21, attract and retain T cells in lymph nodes (LNs), but whether this function …

10.7554/eLife.03180.001 The co-stimulatory molecule CD28 is essential for activation of
helper T cells. Despite this critical role, it is not known whether CD28 has functions in …

The failure to generate enduring humoral immunity after vaccination is a hallmark of advancing
age. This can be attributed to a reduction in the germinal center (GC) response, which …

Although the simultaneous engagement of multiple effector mechanisms is thought to
characterize optimal CD8 + T-cell immunity and facilitate pathogen clearance, the differentiation …