The mutual and interdependent interaction between tumor and its microenvironment is a
crucial topic in cancer research. Recently, it was reported that targeting stromal events could …

Breast cancer consists of highly heterogeneous tumors, whose cell of origin and driver
oncogenes are difficult to be uniquely defined. Here we report that MYC acts as tumor …

Notwithstanding cancer patients benefit from a plethora of therapeutic alternatives, drug
resistance remains a critical hurdle. Indeed, the high mortality rate is associated with metastatic …

Thyroid carcinoma (TC) is the most common malignancy of endocrine organs. The cell
subpopulation in the lineage hierarchy that serves as cell of origin for the different TC histotypes …

Obesity is a strong risk factor for cancer progression, posing obesity-related cancer as one
of the leading causes of death. Nevertheless, the molecular mechanisms that endow cancer …

Objective Cancer stem cells are responsible for tumour spreading and relapse. Human
epidermal growth factor receptor 2 (HER2) expression is a negative prognostic factor in …

Cancer can be considered an aberrant organ with a hierarchical composition of different cell
populations. The tumor microenvironment, including the immune cells and related cytokines…

Cancer stem cells (CSCs) are the tumor cell subpopulation responsible for resistance to
chemotherapy, tumor recurrence, and metastasis. An efficient therapy must act on low …

Metastatic disease represents the major cause of death in oncologic patients worldwide.
Accumulating evidence have highlighted the relevance of a small population of cancer cells, …

The identification of reciprocal interactions between tumor-infiltrating immune cells and the
microenviroment may help us understand mechanisms of tumor growth inhibition or …