The co-chaperone BAG3, in complex with the heat shock protein HSPB8, plays a role in
protein quality control during mechanical strain. It is part of a multichaperone complex that …

Aberrations in nuclear size and shape are commonly used to identify cancerous tissue.
However, it remains unclear whether the disturbed nuclear structure directly contributes to the …

The small heat shock protein HSPB8 and its co-chaperone BAG3 are proposed to regulate
cytoskeletal proteostasis in response to mechanical signaling in muscle cells. Here, we show …

The fidelity of actin dynamics relies on protein quality control, but the underlying molecular
mechanisms are poorly defined. During mitosis, the cochaperone BCL2-associated …

This study details the clinical and cellular phenotypes associated with two missense heterozygous
mutations in LMNA, c.1745G>T p.(Arg582Leu), and c.1892G>A p.(Gly631Asp), in two …

The cochaperone BCL2-associated athanogene 3 (BAG3), in complex with the heat shock
protein HSPB8, facilitates mitotic rounding, spindle orientation, and proper abscission of …

Laminopathies are rare and heterogeneous diseases affecting one to almost all tissues, as
in Progeria, and sharing certain features such as metabolic disorders and a predisposition to …

Lamin A/C is a well-established key contributor to nuclear stiffness and its role in nucleus
mechanical properties has been extensively studied. However, its impact on whole-cell …

Many proteins are causative for inherited partial lipodystrophies, including lamins, the
essential constituents of the nuclear envelope scaffold called the lamina. By performing high …

Small heat shock proteins (HspB proteins) form a diverse family of proteins that have evolved
distinct modes of action to protect cells from proteotoxic stress. Studies conducted within …